The study of bone marrow histology in murine models?
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The study of bone marrow histology in murine models involves the analysis of the complex structural organization and cellular interactions within the bone marrow microenvironment . Various techniques, such as histological sectioning, immunohistochemistry, and in vivo microscopy, are used to investigate the leukemic bone marrow niche and understand the progression of chronic myelogenous leukemia and other leukemias . Additionally, the metabolomic profile of bone marrow cells can be evaluated using gas chromatography-coupled mass spectrometry to assess the impact of alcohol consumption on immune cell function . Furthermore, the spatial colocalization of plasma cells, eosinophils, and B cells within the bone marrow can be analyzed using confocal fluorescence microscopy and image-based systems biology approaches . Standardized and efficient methods for bone dissection and bone marrow isolation are also described for downstream applications, including histomorphologic analysis, strength testing, cell sorting, and DNA, RNA, and protein extraction .
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| The paper does not specifically mention the study of bone marrow histology in murine models. The paper primarily focuses on the dissection of murine long bones and the isolation of bone marrow for downstream applications such as cell sorting, primary cell culture, and DNA/RNA/protein extraction. | |
| The paper does not specifically mention the study of bone marrow histology in murine models. The paper focuses on the quantitative analysis of cell colocalization in murine bone marrow using confocal fluorescence microscopy images. | |
1 Citations | The paper provides a detailed experimental protocol for the generation of thick slices of murine bone marrow, immunostaining, and optical clearing for high-resolution 3D microscopy. |
| The paper discusses the use of histological analysis and immunohistochemistry to study the bone marrow microenvironment in a murine model of chronic myelogenous leukemia (CML). | |
| The provided paper does not discuss the study of bone marrow histology in murine models. |
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