What are major gaps about Wolbachia strain wAu in Aedes albopictus?
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Major gaps regarding Wolbachia strain wAu in Aedes albopictus include its unique antiviral features compared to other strains, such as wMel and wAlbA, despite not exhibiting the same cholesterol sequestration phenotype as wMel . Additionally, the proteomic analysis of wAu-carrying midguts revealed distinct differences in lipid transport and metabolism compared to other Wolbachia strains, indicating potential perturbations in RNA processing pathways contributing to virus inhibition . Furthermore, the study highlights the need to further investigate the cellular mechanisms underlying wAu's antiviral activity, as its response differs from other characterized Wolbachia strains like wMel and wAlbA, emphasizing the gaps in understanding the specific mechanisms of wAu-mediated virus inhibition in Aedes albopictus .
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| Major gaps about Wolbachia strain wAu in Aedes albopictus include limited understanding of prevalence, molecular characterization, and its relationship with dengue outbreaks in different regions, particularly in China. | |
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