What are the common histopathological changes observed in mice affected by typhoid fever?
Histopathological changes observed in mice affected by typhoid fever include severe sloughing and desquamation with cellular debris in the lumen of the intestine, lung, liver, spleen, and kidney . In addition, there is severe suppuration with congestion, extension destruction of liver parenchyma, severe hemorrhage of splenic parenchyma with atrophy of white pulp, and severe congestion with hemosiderin pigment deposition and active hyperemia and congestion between renal tubules . These changes are accompanied by fever, splenomegaly, cytopenias (anemia, thrombocytopenia), hemophagocytosis in bone marrow and spleen, hyperferritinemia, and hypofibrinogenemia . The severity of the disease correlates with high splenic and hepatic bacterial load . Extensive anatomical changes are observed in the liver and spleen, including stasis, swelling of Kupffer cells, necrotic foci, histiocytic-monocytic nodules, widespread thrombosis of branches of the portal and splenic veins, and extensive areas of necrosis .
Answers from top 5 papers
Papers (5) | Insight |
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Not addressed in the paper. | |
Histopathological changes in mice with Salmonella infection include liver and spleen alterations like stasis, Kupffer cell swelling, necrotic foci, thrombosis, and necrosis, appearing earlier in susceptible mice. | |
Histopathological changes in mice with typhoid fever include increased hemophagocytic macrophages in bone marrow and spleen, fever, splenomegaly, cytopenias, hyperferritinemia, and hypofibrinogenemia. | |
Histopathological changes in the liver induced by Salmonella typhi in Wistar rats include hepatotoxicity. Chromolaena odorata extract reversed these changes effectively, outperforming ciprofloxacin in a dose-dependent manner. | |
Open access•Journal Article | The provided paper is about the pathology of internal organs in mice infected with Salmonella mbandaka, not typhoid fever. The paper does not provide information about histopathological changes in mice affected by typhoid fever. |