What are the current developments and future prospects for light-sheet microscopy in biomedical research and beyond?
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Light-sheet fluorescence microscopy (LSFM) has seen significant developments and holds promising future prospects in biomedical research and beyond. LSFM enables rapid and non-invasive 3D imaging with high spatial-temporal resolution, making it suitable for various applications in biology and medicine . Current developments in LSFM include smart and adaptive imaging schemes, where the microscope autonomously decides imaging parameters, and image restoration techniques to overcome traditional trade-offs in resolution, field of view, and sample health . LSFM has been applied in developmental biology, pathology, microfluidics, tissue imaging, diagnostics, and cytometry . Furthermore, LSFM has the potential to revolutionize medical diagnostics by offering nondestructive 3D pathology, allowing visualization of tissue within its natural volumetric context . The use of LSFM in translational investigations, preclinical drug development, and clinical decision-support assays is also anticipated . In addition, advancements in LSFM have led to the development of compact and low-cost imaging technology with cellular resolution, making it suitable for ex vivo and in vivo imaging of biological tissue .
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13 Mar 2023 | The provided paper discusses the use of incoherent light detection in light sheet microscopy, but it does not provide information about current developments and future prospects for light-sheet microscopy in biomedical research and beyond. |
| The provided paper does not discuss the current developments and future prospects for light-sheet microscopy in biomedical research and beyond. | |
| The paper discusses the recent advances in nondestructive 3D pathology using light-sheet fluorescence microscopy for translational research and clinical assays, but it does not specifically mention the current developments and future prospects for light-sheet microscopy in biomedical research and beyond. | |
| The paper discusses current and future developments in light-sheet microscopy, including smart and adaptive imaging schemes, image restoration techniques, and open top light-sheet microscopes for multi-modal imaging. | |
| The paper discusses the major developments of light-sheet fluorescence microscopy (LSFM) for adoption in both research and clinical applications, including tissue imaging, diagnostics, and cytometry. It does not specifically mention future prospects for LSFM. |
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