What are the different steps to synthesize paracetamol ?
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Paracetamol can be synthesized through several different steps. First, nitrobenzene is hydrogenated in boron trifluoride ether and aqueous solution to obtain para amino phenol . Then, rearrangement reaction synthesis and acetylation are performed to prepare APAP . Another method involves using supercritical carbon dioxide as an anti-solvent to precipitate paracetamol and betaine in a mole ratio of 1:1 or 1:2, resulting in a paracetamol-betaine cocrystal . Additionally, a method using NIR spectroscopy has been developed to determine various physical and chemical parameters of paracetamol tablets, such as API content, particle size, and compaction pressure . Overall, the synthesis of paracetamol involves hydrogenation, rearrangement reaction synthesis, acetylation, and cocrystallization, with the potential for quality control using NIR spectroscopy.
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Open access 01 Jan 2014 2 Citations | The paper does not provide information about the specific steps to synthesize paracetamol. |
44 Citations | The different steps to synthesize paracetamol include weighing of the API and excipients, mixing, granulation, drying, sieving, and tableting. |
| The steps to synthesize paracetamol include catalysis, hydrogenation, acylation, nitrobenzene hydrogenation, rearrangement reaction synthesis, and acetylation. | |
| The method involves adding paracetamol and betaine into an organic solvent, introducing supercritical carbon dioxide as an anti-solvent, and precipitating the cocrystal drug particles. | |
| The given text does not provide information about the synthesis of paracetamol. |
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