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What are the effects lps has on the rat spleen analyzed with pcr?

Platelet transfusion

Sleep restriction

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Lipopolysaccharide (LPS) administration in rats has been shown to have significant effects on the spleen. Studies have revealed that LPS exposure can lead to alterations in gene expression profiles related to innate and adaptive immunity in the spleen, affecting pathways associated with immune responses. Additionally, LPS-induced endotoxemia has been found to impact membrane phospholipids in the spleen, specifically altering major phospholipids and fatty acid composition, potentially leading to immune impairment. Furthermore, LPS exposure can result in the spleen serving as a reservoir of inflammatory myeloid cells that are released into the blood and brain, influencing neuroinflammation and cognitive deficits. These findings collectively highlight the intricate relationship between LPS exposure and the spleen, showcasing the diverse effects on immune responses and inflammatory processes in rats.

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Open access•Journal Article [Effects of soothing liver and invigorating spleen recipes on LPS-induced hepatocytes injury of rats and TLR4/p38MAPK signal pathway] Xiang-Wen Gong, Qinhe Yang, Hai-Zhen Yan, Yupei Zhang, Yin-Ji Liang, Yi-Zhen Liu, Zhang Jin-Wen, Chun-mei Lin, Yuan-Yuan Li - Show less +8 more 01 Oct 2014-China journal of Chinese materia medica 4 Citations	Not addressed in the paper.
Journal Article•DOI Early-Life Exposure to Lipopolysaccharide Induces Persistent Changes in Gene Expression Profiles in the Liver and Spleen of Female FVB/N Mice Elda Dervishi, Dagnachew Hailemariam, Seyed Ali Goldansaz, Burim N. Ametaj - Show less +3 more 08 Jul 2023-Veterinary Sciences	LPS upregulates genes involved in innate and adaptive immunity in the spleen of FVB/N female mice, affecting cytokine production and immune responses, as analyzed by PCR.
Open access•Journal Article•DOI Macrophage Depletion Mitigates Platelet Aggregate Formation in Splenic Marginal Zone and Alleviates LPS-Associated Thrombocytopenia in Rats. Ying Li, Johannah Ryan, Fei Xu, Jaroslav G. Vostal - Show less +3 more 17 Dec 2019-Frontiers of Medicine in China 9 Citations	LPS injection in rats led to increased TNFa, IL-6, IL-1b, and IL-10 levels in the spleen, indicating sepsis development and thrombocytopenia, as observed in the study.
Open access•Journal Article•DOI The spleen mediates chronic sleep restriction-mediated enhancement of LPS-induced neuroinflammation, cognitive deficits, and anxiety-like behavior. Dan Xu, Yujing Zhang, Bing Xie, Hua Yao, Yin Yuan, Shiying Yuan, Jiancheng Zhang - Show less +6 more 03 Aug 2020 9 Citations	Not addressed in the paper.

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What are the effects of LPS infusion in rats?5 answersLPS infusion in rats has various effects. In the brain, LPS can activate astrocytes and microglia, leading to the polarization of different phenotypes such as A1, A2, M1, and M2. In the hypothalamus, LPS injection can decrease the expression of the kisspeptin receptor and RFRP, potentially affecting hormone levels. In the lungs, LPS-induced acute lung injury can be alleviated by intravenous infusion of PFC, which reduces the infiltration of polymorphonuclear neutrophils and expression of inflammatory markers. In the kidneys, LPS can induce oxidative stress, histological changes, DNA damage, and apoptosis, but these effects can be mitigated by antioxidant treatments.

What dose used LPS in brain?5 answersThe dose of LPS used in the brain varied across the studies. In one study by Szot et al., the dose of LPS was not specified. In another study by Wu et al., a high dose of LPS (10 mg/kg) was administered systemically. In a study by Ning et al., a single dose of LPS (500 μg/kg) was injected intraperitoneally. In a study by Hyeji et al., a single low dose of LPS was used, but the specific dose was not mentioned. In a study by Jung et al., a single low dose of LPS was also used, but the specific dose was not provided. Therefore, the specific dose of LPS used in the brain varied across the studies and was not consistently reported.

What is the dose of LPS which decreases autophagy in rat brian?5 answersThe dose of LPS that decreases autophagy in the rat brain is not mentioned in the abstracts provided.

What is the effect of acute acetaminophen toxicity on the spleen in mice?5 answersAcute acetaminophen toxicity in mice has been shown to have an effect on the spleen. The combination of acetaminophen and ethanol significantly decreased the circulating leukocytes and the relative weights of the liver, spleen, and thymus. Additionally, there were significant reductions in splenic plaque forming cells (PFC) and hemagglutination (HA) titers to sheep red blood cells (SRBC) in mice receiving acetaminophen and ethanol. Furthermore, acetaminophen overdose led to acute liver injury in mice, characterized by a decline in the antioxidant defense system, and pre-treatment with Protocatechuic acid (PCA) attenuated the liver histological damage and the antioxidant enzymes. However, it is important to note that the specific effect of acute acetaminophen toxicity on the spleen was not directly addressed in the abstracts provided.

What are the changes in the spleen mass in rats with Alzheimer's?5 answersThe spleen plays a role in the clearance of circulating Aβ in the periphery, and splenectomy can aggravate cognitive impairment and AD-related pathologies in AD mice. The abstracts do not provide information specifically about changes in spleen mass in rats with Alzheimer's.

What are the histological features of the spleen in rats?5 answersThe histological features of the spleen in rats include the presence of white and red pulp, lymphoid nodules, lymphoid sheaths near the vessels, and a trabecular system. The white pulp consists of lymphoid nodules and lymphoid sheaths near the vessels, while the red pulp is formed by the white and red pulp. The relative area of lymphoid nodules in mammals dominates under the area of lymphoid sheaths near the vessels. The spleen is sensitive to biotic, abiotic, and environmental factors, and its morphological features and morphometric parameters are important for the development of organ test-systems. The relative weight of the spleen varies among different animal species, with horses having the greatest relative weight and pigeons having the lowest. The support-contractile apparatus is better developed in horses and sheep, while chickens and rabbits have a lesser-developed support-contractile apparatus.

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