scispace - formally typeset
Search or ask a question

What are the effects of phthalates on the endocrine system? 


Best insight from top research papers

Phthalates, a type of plastic additive, have been found to have negative effects on the endocrine system. They are considered endocrine-disrupting compounds and can interfere with the proper functioning of hormones and signaling molecules in the body . Phthalates have been associated with adverse health outcomes, including reproductive system dysfunction, developmental disorders, and cognitive and behavioral problems . They can induce oxidative stress and cell degenerative processes, leading to damage in various systems of the body . Phthalates have also been linked to metabolic disorders, infertility, growth impairment, and chronic diseases . Prenatal exposure to phthalates has been shown to influence the metabolism of the developing embryo and promote obesity in subsequent generations . Overall, phthalates have significant effects on the endocrine system and can have wide-ranging impacts on human health.

Answers from top 3 papers

More filters
Papers (3)Insight
The paper discusses that phthalates can interfere with the neuroendocrine systems, such as thyroid hormone signaling or metabolism, leading to disruption of neuronal differentiation and maturation.
The paper does not specifically mention the effects of phthalates on the endocrine system. The paper focuses on the effects of phthalates on the human reproductive system and development.
The paper does not specifically mention the effects of phthalates on the endocrine system. The paper focuses on the effects of phthalates on erythrocytes and the reproductive system.

Related Questions

How phthalate impact motoric developmet?5 answersPhthalates have been shown to have adverse effects on motor development, particularly in boys. Mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP) was found to have adverse effects on gross motor skills in boys. Additionally, joint effects were observed between mono-2-ethylhexyl phthalate (MEHP) and MEHHP on gross motor skills in boys. The risk of social development impairment increased with MEHHP exposure during the second trimester. Early gestation was identified as a sensitive window of exposure to high-molecular-weight phthalates (HMWP) for motor development, particularly in boys. These findings suggest that prenatal exposure to phthalates, especially during specific trimesters, can impact motor development, with boys being more vulnerable to the neurotoxic effects of phthalates on motor skills.
What are the effects of phthalate esters on human health?5 answersPhthalate esters, commonly used as plasticizers, have been found to have various effects on human health. These compounds are known to be endocrine disruptors and can accumulate in the human body, leading to negative impacts on health. Phthalates have been associated with adverse effects on the reproductive system, including changes in development and reproduction in both men and women. They have also been linked to respiratory system diseases and a higher incidence of allergies. Some phthalates, particularly the short-chain ones, have been classified as hormonal active agents and have been reported to promote various types of cancer. The presence of phthalates in the environment and their ability to leach out of plastics raise concerns about their potential health risks. Overall, the use of phthalate esters in plastic products and their widespread occurrence in the environment highlight the need to reduce their use and improve their disposal to minimize the negative impacts on human health.
What are the environmental effects of phthalic anhydride?5 answersPhthalates are environmental pollutants that can be released into the environment and contaminate soil and water. They are known to have negative effects on the growth, development, and reproduction of organisms, including humans. Phthalates are endocrine disrupting compounds and have been associated with oxidative stress, alterations in cytokine expression, and allergic diseases such as asthma. They can also affect germline function and increase the rate of aneuploidy, leading to genetic disorders and miscarriages. In addition, phthalates have been found to increase biofilm formation in bacteria and alter bacterial morphology. Overall, phthalates pose a risk to human health and the environment, and reducing exposure to phthalates is advised.
What are the effects of phthaloyl glycine on human health?5 answersPhthaloyl glycine, a phthalimide derivative, did not demonstrate anticonvulsant activity and had poor pharmacokinetics, high clearance, low volume of distribution, and short half-life. However, the phthaloyl glycinamide derivatives showed anticonvulsant activity and had better pharmacokinetic profiles, longer half-life, and mean residence time than phthaloyl glycine. Phthaloyl glycinamide was more potent than valproic acid, a major antiepileptic agent, and showed a better margin between activity and neurotoxicity. Phthaloyl glycine was excreted unchanged in the urine, while the urinary metabolites of the glycinamide derivatives were phthaloyl glycine and phthaloyl glycinamide. In summary, phthaloyl glycine does not have significant effects on human health, but its glycinamide derivatives show anticonvulsant activity with better pharmacokinetic profiles.
Does exposure to phthalates affect thyroid function?3 answersExposure to phthalates has been found to affect thyroid function. Several studies have shown associations between specific phthalate metabolites and indicators of thyroid function in adults. These associations include increased levels of total triiodothyronine (TT3) and free thyroxine (FT4) with overall phthalate metabolite concentrations. Additionally, certain phthalate metabolites have been linked to altered thyroid-stimulating hormone (TSH) levels. The mechanisms through which phthalates affect thyroid function are not fully understood, but oxidative and nitrosative stress have been suggested as potential mediators. It is important to note that the studies mentioned are cross-sectional in nature, limiting causal inference. Further research is needed to better understand the relationship between phthalate exposure and thyroid function.
What are the endocrine disruptive effects of pesticides?5 answersPesticides have been found to have endocrine disruptive effects, posing a potential threat to human health. Some pesticides, such as Methiocarb, have been classified as endocrine disruptors due to their interference with estrogen signaling. Other pesticides, including vinclozolin, atrazine, and cypermethrin, have been shown to reduce the expression of RACK1, a protein under steroid hormone control, leading to alterations in immune response. Glyphosate, thiacloprid, and imidacloprid have been found to interfere with estrogen biosynthesis and/or signaling, indicating their potential as endocrine disruptors. The use of pesticides in agriculture has been linked to adverse changes in the nervous and endocrine systems, with oxidative stress, neuroinflammation, and epigenetic modification identified as potential mechanisms. Additionally, a virtual screening approach identified several pesticides, including flucythrinate, fluvalinate, bifenthrin, cyhalothrin, and cypermethrin, as potential multi-target ligands for proteins associated with breast cancer.

See what other people are reading

How MDA serves as a biomarker for toxicity in fish liver?
4 answers
Malondialdehyde (MDA) is utilized as a biomarker for toxicity in fish liver due to its association with lipid peroxidation. Exposure to contaminants like 2,4-Dinitrochlorobenzene (CDNB) and phthalates induces a significant increase in MDA levels in fish liver, indicating oxidative stress and potential toxicity. Studies on microplastic exposure demonstrate elevated MDA levels in fish liver, reflecting oxidative damage and activation of detoxifying mechanisms. The measurement of MDA, along with antioxidant enzyme activities like SOD, CAT, and GPx, provides insights into the extent of oxidative stress and the response to toxicants in fish liver. Therefore, MDA serves as a valuable indicator of oxidative damage and toxicity in fish liver, aiding in the assessment of environmental contaminants' impact on aquatic organisms.
What is gc-ms?
5 answers
Gas Chromatography-Mass Spectrometry (GC-MS) is a powerful analytical technique extensively used in various fields such as metabolomics and bioactive compound analysis. GC-MS allows for the simultaneous measurement of a wide range of compounds, including organic acids, amino acids, sugars, and fatty acids. In the context of herbal plants, GC-MS is utilized to identify bioactive compounds like alkaloids, terpenoids, flavonoids, and glycosides, which are crucial for their therapeutic effects. Moreover, in the study of Sphenocentrum jollyanum, GC-MS was employed to analyze the ethanol extract and identify 45 bioactive compounds, showcasing its utility in determining the composition of plant extracts. Overall, GC-MS plays a vital role in identifying and quantifying compounds in complex mixtures, making it an invaluable tool in research and diagnostics.
When phthalate esters were banned or restricted by China, EU, and America?
5 answers
China, the EU, and the USA have implemented varying restrictions on phthalate esters. In the EU, bis(2-Ethylhexyl) phthalate (DEHP), Butylbenzyl phthalate (BBP), Dibutyl phthalate (DBP), and Diisobutyl phthalate (DIBP) are not allowed in toys and childcare articles above 0.1% by weight. China restricts DBP, BBP, DEHP, Di-n-octyl phthalate (DNOP), Diisobutyl phthalate (DIBP), and Diisodecyl phthalate (DIDP) in plastic toys to 0.1% of the material composition and prohibits DEHP, BBP, and DBP in cosmetics. In the USA, there is no formal prohibition on phthalates in cosmetics, but they are mostly limited in Food Contact Materials (FCM). The EU has also banned the use of BBP in cosmetics. These regulations highlight the discrepancies in international legislation regarding phthalate esters.
What are the legistation on phthalate esters in China?
4 answers
In China, legislation regarding phthalate esters (PAEs) is crucial due to their widespread presence and associated risks. Studies from various regions highlight the need for regulatory measures. Research in Jingmen emphasizes the importance of controlling PAEs in intensively managed greenhouses and nominates DEHP as a priority compound due to its high residuals and risks to human health, especially in children. Investigations in Shaanxi Province underscore the ecological risks posed by PAEs in wastewater, with certain compounds showing medium to high risk levels. Studies in Beijing reveal high concentrations of PAEs in soils, particularly in areas with intensive human activities, indicating the need for stringent controls. Additionally, research on indoor dust across China suggests that PAEs from various sources pose noncancer risks to humans, especially children, emphasizing the importance of regulating these compounds in indoor environments.
How to extract DEHP from beverages?
5 answers
DEHP extraction from beverages can be achieved through various methods outlined in the research papers. One method involves using a two-step process with hexane extraction followed by HPLC separation. Another effective approach is the utilization of a solid-phase extraction (SPE) technique with COF materials, showing high recovery rates and reusability for DEHP extraction. Additionally, ultrasound–vortex-assisted dispersive liquid–liquid microextraction (UVA-DLLME) coupled with gas chromatographic analysis has been proven successful for DEHP extraction from hot beverages, ensuring precision and reproducibility. Furthermore, a microdispersive solid-phase extraction method utilizing multiwalled carbon nanotubes has been developed for DEHP extraction from tap water and various beverages, demonstrating high recovery rates and low limits of quantification. These methods provide efficient ways to extract DEHP from beverages for further analysis and monitoring.
How does toxicant element influence the maternal behavior in mice throughout generations?
5 answers
Maternal exposure to toxic elements like lead (Pb), cadmium (Cd), trichloroethane (TCE), and environmental pollutants can significantly impact maternal behavior in mice across generations. Studies show that exposure to Pb during pregnancy leads to sex-dependent basal developmental changes in glial cells and increased prevalence of autistic-like behaviors in offspring. Similarly, maternal Cd exposure results in increased heart weights in newborns and susceptibility to hypertension in adulthood, possibly due to altered cellular metabolic pathways and hypoxic conditions during fetal development. TCE exposure is linked to abnormalities in birth weight and neonatal neurobehavior, indicating a role of environmental toxicants in maternal behavior. Furthermore, exposure to traffic-related air pollutants can trigger immune responses in mothers, affecting fetal brain and lung inflammation, ultimately impacting neurocognitive outcomes in offspring.
What is the photocatalytic activity of Ag/Ag2CO3 compared to other materials used in water purification?
4 answers
The photocatalytic activity of Ag/Ag2CO3-based materials in water purification demonstrates significant advantages over other materials, primarily due to its enhanced efficiency in degrading pollutants under UV or visible light exposure. Ag2CO3-based photocatalysts, including those doped with silver, have been recognized for their ability to absorb a larger fraction of the solar spectrum, which is crucial for the efficient degradation of contaminants such as endocrine-disrupting chemicals (EDCs). This characteristic is partly attributed to the unique properties of Ag2CO3, such as its wide band gap, non-toxicity, and low cost, which are essential for sustainable water treatment solutions. Comparatively, TiO2 photocatalysis, another widely studied method for water treatment, primarily relies on UV irradiation for the activation of photocatalysts. Although TiO2 is effective in degrading organic pollutants, the requirement for UV light limits its practical application under natural sunlight. In contrast, Ag/Ag2CO3-based materials, such as Ag/Ag2O/ZnO composites, have shown superior performance in degrading organic pollutants like dibutyl phthalate (DBP) under UV light, with a degradation efficiency four times higher than that of ZnO alone. Moreover, the development of Ag2CO3/g-C3N4 nanocomposites has further enhanced photocatalytic activity under visible light, outperforming single catalysts like Ag2CO3 or g-C3N4 in the degradation of dyes. This improvement is attributed to the synergistic effect between Ag2CO3 nanoparticles and g-C3N4 nanosheets, which facilitates the separation of photogenerated charge carriers. Additionally, modifications with other materials such as Ag/α-Fe2O3 have been explored, resulting in multifunctional water purification materials that not only degrade organic dyes but also exhibit antibacterial activity. The integration of silver with other photocatalytic materials, including Ag2S/ZnO and TiO2 doped with silver nanoparticles, has shown to enhance the photocatalytic degradation of pollutants like phenol and methylene blue, respectively, under visible light. In summary, Ag/Ag2CO3-based materials demonstrate superior photocatalytic activity compared to other photocatalysts like TiO2, primarily due to their enhanced light absorption capabilities, efficient degradation of pollutants, and the potential for multifunctional water purification applications.
Could perfume cause cancer?
5 answers
Perfumes contain chemicals like phthalates, aldehydes, and parabens, which are linked to health risks. Studies have shown that phthalate esters, commonly found in perfumes, may pose health risks, with di (2-ethylhexyl) phthalate having potential carcinogenic effects. Furthermore, research on environmental exposures among minority cancer survivors revealed ubiquitous exposure to chemicals found in personal care products, including perfumes, raising concerns about potential health impacts. While perfumes themselves may not directly cause cancer, the chemicals they contain, such as volatile organic compounds (VOCs), have been studied as potential biomarkers for various cancers, indicating a possible indirect link between perfume use and cancer development. Therefore, while perfumes may not directly cause cancer, the chemicals in them could contribute to health risks associated with cancer development.
What are the compositions of marine plastics?
10 answers
Marine plastics are composed of a variety of synthetic polymers and additives, reflecting their diverse sources and applications. The primary polymers identified in marine environments include polyethylene (PE), polypropylene, polystyrene, polyamide, chlorinated PE, and chlorosulfonated PE. These materials are known for their resistance to oxidative ageing and microbial degradation, which contributes to their persistence in coastal and oceanic waters. The complexity of marine plastic pollution is further compounded by the presence of organic plastic additives (OPAs) and inorganic plastic additives (IPAs). OPAs such as diethylhexyl phthalate, dibutyl phthalate, and benzaldehyde, among others, are incorporated into plastics for various functional benefits but pose environmental risks upon leaching. IPAs, including titanium dioxide nanoparticles (TiO2-NPs), barium, sulphur, and zinc, have been identified, with TiO2-NPs being of particular concern due to their potential release upon polymer degradation. The environmental impact of these compositions is significant, as plastics act as vectors for chemical contaminants, including hydrocarbons, UV-stabilizers, antioxidants, plasticizers, and flame retardants, which can leach out and accumulate in marine ecosystems. Moreover, the interaction of plastics with marine biota, such as through the formation of the Plastisphere, introduces additional complexities. The Plastisphere, a microbial community that colonizes plastics, can influence the fate of plastics in the marine environment and their interactions with surrounding ecosystems. Biodegradable plastics, such as those based on starch, have been introduced as potential solutions to mitigate pollution. However, their degradation rates and the formation of fouling communities on these materials in marine environments indicate that they may not be a straightforward solution. The comprehensive understanding of marine plastic compositions and their environmental interactions underscores the need for targeted actions to address this pervasive issue.
What are the types of marine plastics?
10 answers
Marine plastics encompass a wide variety of types, reflecting the diversity of plastic products and their degradation processes in marine environments. Macroplastics and microplastics are the primary categories, with macroplastics causing entanglement and habitat loss, and microplastics entering the food web through ingestion by marine organisms. The types of polymers identified in marine microplastics include polyethylene (PE), polypropylene, polystyrene, polyamide, chlorinated PE, and chlorosulfonated PE, with additives such as diethylhexyl phthalate and titanium dioxide nanoparticles, indicating a complex composition that varies by location. Marine plastics also serve as habitats for eukaryotic microbial communities, including harmful species, which suggests that plastics can act as vectors for the spread of these organisms. Spectroscopic techniques have identified consumer plastics and marine plastic debris (MPD) types, including those altered by environmental weathering, highlighting the presence of various plastic types in the marine environment. Persistent plastics, which degrade into micro- and nanoplastics, contain chemical additives and contaminants, posing risks to marine ecosystems and food chains. In the western tropical and sub-tropical Atlantic Ocean, microplastics from primary and secondary sources contaminate various environmental compartments, with ingestion by marine biota confirmed in vertebrate groups. Studies on the colonization of plastics by marine microorganisms have shown that non-biodegradable and biodegradable polymers attract different bacterial communities, affecting the ecological impacts and fate of these plastics. The persistence of plastics in marine environments is attributed to their resistance to oxidative ageing and microbial degradation. Deep pelagic waters contain significant concentrations of microplastics, suggesting a large, underappreciated reservoir of marine microplastics. Finally, benthic plastic debris, influenced by various factors including proximity to urban areas and fishing activities, represents another significant category of marine plastics.
What is the implication of black ink in attention?
5 answers
Black tattoo inks, particularly black ones, contain various compounds like carbon nanoparticles, polycyclic aromatic hydrocarbons (PAHs), and additives. These inks can induce the formation of reactive oxygen species (ROS), potentially leading to minor clinical symptoms. Additionally, hazardous substances found in black tattoo inks, such as dibutyl phthalate and hexachloro-1,3-butadiene, can have sensitizing, genotoxic, and cytotoxic effects, contributing to adverse skin reactions. The attention-scatter reduction conditions using a black light apparatus have shown that stimuli presented under such conditions can enhance retention in learning tasks. Therefore, the presence of black ink in tattoos may have implications on attention due to the chemical composition and potential skin reactions associated with these inks.