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What are the most effective therapies against long covid?

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The most effective therapies against long covid have not been explicitly mentioned in the provided abstracts.

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Open access•Journal Article•DOI Can artificial intelligence identify effective COVID-19 therapies? Michael B. Schultz, Daniel L. Vera, David A. Sinclair - Show less +2 more 07 Aug 2020-Embo Molecular Medicine 13 Citations	The text does not provide information about the most effective therapies against long COVID.
Open access•Journal Article•DOI Cutaneous long COVID. Antonella Tammaro, Francesca Romana Parisella, Ganiyat Adenike Ralitsa Adebanjo - Show less +2 more 15 Jun 2021-Journal of Cosmetic Dermatology 7 Citations	The text does not provide information about the most effective therapies against long covid.
Open access•Posted Content•DOI Effectiveness of Ivermectin-Based Multidrug Therapy in Severe Hypoxic Ambulatory COVID-19 Patients Sabine Hazan, Sonya Dave, Anoja W. Gunaratne, Sibasish Dolai, Peter A. McCullough, Robert R. Clancy, Thomas J. Borody - Show less +6 more 07 Jul 2021-medRxiv 2 Citations	The most effective therapy against long COVID is a combination of ivermectin, doxycycline, zinc, and Vitamins D and C.
Open access•Journal Article•DOI Alternative therapies for Covid-19. G. Sundararajan, Prince J. Isaac, V. Andal, R. Lakshmipathy - Show less +3 more 05 Aug 2021-Materials Today: Proceedings	The paper does not mention anything about the most effective therapies against long covid.
Open access•Journal Article•DOI Alternative therapies for Covid-19 01 Jan 2022-Materials Today: Proceedings	The paper does not mention anything about the most effective therapies against long covid.

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What is long covid?5 answersLong COVID refers to a chronic condition that persists after the acute phase of COVID-19, characterized by a diverse array of persistent symptoms lasting for months to years. Symptoms include cough, fatigue, myalgia, anosmia, and dyspnea, with at least one symptom experienced by the majority of individuals post-acute infection. The pathophysiology of Long COVID involves factors like viral persistence, immune system abnormalities, dysregulated inflammatory response, and microthrombi formation, leading to multisystemic symptoms. Proposed mechanisms include coagulopathy as a main driver, potentially exacerbated by the spike protein of SARS-CoV-2, suggesting a need for targeted treatments like anticoagulants and antiplatelet drugs. Long COVID poses a significant global challenge, impacting individuals of all ages and necessitating further research for effective management and treatment guidelines.

How can Chinese medicine treat long COVID?5 answersChinese medicine has shown efficacy in treating long COVID symptoms. Traditional Chinese medicine (TCM) formulations like Liujunzhi Decoction, Shashen Maidong Decoction, and Bufei Huoxue Capsule have been recommended for post-acute COVID-19 patients, addressing symptoms such as fatigue, dyspnea, and insomnia. TCM treatments have been reported to alleviate symptoms during the convalescence period, potentially due to their ability to resist cytokine storms, improve coagulation abnormalities, and target myocardial damage. These treatments not only relieve symptoms but also improve physiological indicators and pulmonary fibrosis, showcasing their rehabilitative effects on patients recovering from COVID-19. The scientific community recommends further research to confirm the specific actions and mechanisms of TCM in treating long COVID, highlighting its potential therapeutic advantages in managing the complex symptoms of post-COVID syndrome.

What are the treatments for long covid?5 answersTreatment options for long COVID include acupoint stimulation therapy, agents that restore dorsolateral prefrontal cortex (dlPFC) physiology such as N-acetyl cysteine and guanfacine, triple anticoagulant therapy to normalize clotting physiology and reverse endothelialitis, and a functional medicine approach that addresses adrenal fatigue, gut health, inflammation resolution, histamine imbalance, and vitamin D deficiency. Additionally, Kampo medicine, a Japanese traditional medicine, has been used alone or in combination with Western medications to treat long COVID symptoms.

What are various interventions in the literature for long covid? And which ones have data in patients?4 answersVarious interventions for long COVID-19 have been explored in the literature. These interventions include olfactory rehabilitation combined with oral supplementation, aromatherapy, psychological interventions, pharmacological and other medical interventions, herbal, nutritional, or natural supplement interventions, cognitive and neurorehabilitation interventions, and physiotherapy or physical rehabilitation.However, data specifically in patients with long COVID-19 is limited. Only two intervention studies have been found, one focusing on olfactory dysfunction and the other on fatigue.More intervention studies are needed to investigate potentially positive interventions for long COVID-19 symptoms.The breadth and scope of research on interventions for mental health, cognition, and psychological wellbeing in long COVID-19 patients remains limited, and it is crucial for researchers to expand upon the current research to generate high-quality evidence on a wide range of candidate interventions for diverse long COVID-19 patient populations.

What is the best treatment for long covid?5 answersTriple anticoagulant therapy, including dual antiplatelet therapy (DAPT) and a direct oral anticoagulant (DOAC), appears to be a promising treatment option for Long COVID, as it normalizes clotting physiology and reverses endothelialitis. Long-term high-dose immunoglobulin therapy has also shown to be effective in treating patients with Long COVID, improving their clinical symptoms. Additionally, hyperbaric oxygen therapy and the use of adaptogens have shown promising results in decreasing fatigue, while melatonin can be beneficial for insomnia and poor sleep hygiene in Long COVID patients. Nirmatrelvir/ritonavir has also demonstrated an optimal response in a patient with persistent prolonged symptoms. However, further controlled clinical studies are needed to evaluate the efficacy and safety of these treatment options for Long COVID.

What are the available treatments for COVID-19?4 answersPassive immunization through monoclonal antibodies has shown positive impact on the clinical evolution of COVID-19, especially in outpatients or inpatients without oxygen supply. Ritonavir-boosted nirmatrelvir and remdesivir are direct antiviral treatments that are currently being used for the management of early infections. Anti-inflammatory treatments, such as dexamethasone, tocilizumab, JAK inhibitors, and anakinra, have been effective in inpatients with oxygen supply. Other treatments that have shown potential effects on COVID-19 symptoms include tetracycline, corticosteroids, zinc, curcumin, traditional herbal medicine, vitamin D, photobiomodulation, malic acid sialagogue, chewing gum, acupuncture, and moxibustion. Antiviral drugs, anti-SARS-CoV-2 monoclonal antibodies, and traditional Chinese medicine are also being explored as treatment options. Currently, there are authorized treatments in Canada that include neutralizing antibodies and antivirals. The main therapeutic options for severe and critical illness involve modulating the host inflammatory response to SARS-CoV-2 infection.

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