What are the potential benefits of developing a new dosage form of methoxsalen for the treatment of psoriasis?
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Developing a new dosage form of methotrexate (MTX) for psoriasis treatment offers various benefits. Different formulations like MTX-loaded electrospun nanofibrous patches, solid-lipid nanoparticles (SLN-MTX), nanostructured lipid carriers (MTXNLCs), dissolving microneedle (MN) patches, and MTX-olive oil nanoemulsion have shown promising results. These formulations provide controlled release, enhanced skin permeation, improved anti-psoriatic activity, reduced systemic side effects, and better therapeutic responses . Specifically, the new dosage forms exhibit slow and sustained drug release, increased drug permeation through the skin, enhanced distribution in target organs, dose-dependent inhibition of keratinocyte growth, and improved therapeutic outcomes with minimized side effects. Overall, these innovative formulations represent a significant advancement in psoriasis treatment, offering safer and more effective alternatives to traditional MTX administration methods.
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| Papers (5) | Insight |
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Open access•Journal Article 5 Citations | The new methotrexate-olive oil nano-emulsion offers enhanced skin permeation, efficient drug release, and potential for managing psoriasis due to its optimized formulation characteristics. |
145 Citations | The new dosage form of methotrexate in a dissolving microneedle patch offers improved skin penetration, precise dosing, reduced systemic toxicity, enhanced efficacy, and better patient compliance for psoriasis treatment. |
| The new dosage form of Methotrexate-loaded Nanostructured Lipid Carrier Gel shows improved cutaneous bioavailability, reduced systemic side effects, enhanced drug deposition, and better anti-psoriatic activity for treating psoriasis. | |
1 Citations | The novel methotrexate-loaded electrospun patch offers controlled release, improved skin permeation, and minimized systemic side effects, making it a promising long-acting topical treatment for psoriasis plaques. |
| The solid-lipid nanoparticles formulation of methotrexate (SLN-MTX) offers benefits like controlled release, enhanced skin permeation, improved organ distribution, and effective inhibition of keratinocyte growth for psoriasis treatment. |
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