What are the potential future developments and applications of functional amyloid-based therapies for treating diseases?
Best insight from top research papers
Functional amyloids have emerged as a promising avenue for therapeutic interventions in various diseases. One innovative approach involves the development of "proteolytic functional amyloids (PFA)" that can selectively target and degrade pathogenic amyloids, offering a potential strategy for combating amyloid-related disorders . Additionally, the use of amyloid-binding covalent organic frameworks (COFs) has shown promise in preventing beta-amyloid aggregation, potentially offering a novel therapeutic option for diseases like Alzheimer's . Furthermore, the fabrication of CBD-containing functional amyloid-chitin complexes presents opportunities for diverse applications, including in biomedicine, tissue engineering, and electronics, showcasing the versatility and potential of functional amyloid-based therapies in future developments . These advancements highlight the exciting prospects of leveraging functional amyloids for innovative therapeutic strategies in the treatment of various diseases.
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| Papers (5) | Insight |
|---|---|
18 Citations | Functionalized two-dimensional covalent organic frameworks show promise in preventing beta-amyloid aggregation, destabilizing amyloid structures, and potentially treating Alzheimer's disease, suggesting future therapeutic applications in neurodegenerative diseases. |
2 Citations | Functional amyloids like Proteolytic Functional Amyloids (PFAs) show promise in selectively degrading pathogenic amyloids, inhibiting aggregation, and breaking down fibrillar amyloids, offering a novel approach for treating amyloid-related diseases. |
1 Citations | Potential future developments include biocatalysis, tissue engineering, biomedicine, photonics, and electronics applications of functional amyloid-chitin hybrid ink structures, enabling diverse therapeutic advancements in disease treatment. |
| Future developments may include multifunctional theranostic agents like SLCOOH for real-time imaging of amyloid-β and therapeutic treatment of multiple pathologies in Alzheimer's disease, showcasing promising applications in disease intervention. | |
| Not addressed in the paper. |
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