What are the potential risks and complications associated with the use of in vivo treatment for electrospun vascular grafts?
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The in vivo treatment of electrospun vascular grafts presents several potential risks and complications. These include slow biodegradation, ineffective cellularization, mineralization, and intimal hyperplasia. Mechanical properties are crucial to prevent graft failure, and issues like compliance mismatch can lead to complications such as intimal hyperplasia, suture site rupture, and cell damage . Furthermore, risks of thrombosis, calcification, and stenosis are associated with these grafts, highlighting the importance of addressing hemocompatibility and long-term functionality . Despite advantages like good endothelialization, the challenges of maintaining proper degradation rates, cellular response, and preventing adverse tissue reactions underscore the need for further research to enhance the overall performance and safety of electrospun vascular grafts in clinical applications.
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| In vivo treatment with electrospun Pellethane-based vascular grafts showed advantages over ePTFE, with potential risks including neointima thickness stabilization and long-term functioning without stenosis. | |
27 Sep 2021 5 Citations | Potential risks and complications of in vivo treatment for electrospun vascular grafts include low hemocompatibility, thrombosis, intimal hyperplasia, and graft infection, especially with synthetic grafts like Dacron® and Teflon®. |
| Potential risks of in vivo treatment for electrospun vascular grafts include slow biodegradation, ineffective cellularization, mineralization, and intimal hyperplasia, despite advantages like excellent endothelialization and good surgical outcomes. | |
| Potential risks of in vivo treatment for electrospun vascular grafts include intimal hyperplasia, thrombosis, aneurysm, blood leakage, and occlusion, emphasizing the importance of mechanical stability for graft performance. | |
01 Jan 2023 | In vivo risks of electrospun vascular grafts include compliance mismatch, intimal hyperplasia, thrombus formation, and suture site damage due to material type and fiber orientation. |
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