What are the specific factors that influence the clinical response to IV ketamine therapy in patients?
Best insight from top research papers
Specific factors influencing the clinical response to IV ketamine therapy in patients include the pain pattern and chronic primary pain category, which are associated with a favorable response to ketamine treatment . Additionally, the severity of pain symptoms at baseline significantly moderates the antidepressant response to ketamine, with patients experiencing severe pain showing greater improvement in depressive symptoms . Staging models for treatment-resistant depression (TRD) have not accurately predicted response to acute ketamine treatment, suggesting the need for further exploration of predictors such as age and history of neuromodulation therapy . Younger age is associated with a faster response to ketamine over multiple infusions, although age does not predict treatment durability or total efficacy . Anxious depression does not significantly impact outcomes in patients with TRD receiving IV ketamine infusions, as ketamine is effective in treating depression regardless of baseline anxiety levels .
Answers from top 5 papers
More filters
| Papers (5) | Insight |
|---|---|
01 Dec 2021 | Baseline anxiety symptoms do not significantly impact the response to IV Ketamine therapy in treatment-resistant depression patients. Depression symptoms show greater improvement compared to anxiety symptoms. |
9 Citations | Age influences the temporal response to serial ketamine infusions for treatment refractory depression, with younger patients showing faster improvement over six infusions, but age does not affect treatment durability. |
| Pre-treatment pain symptoms significantly influence the antidepressant response to IV ketamine therapy in patients with depression, with those experiencing severe pain showing greater improvement. | |
| Intermittent pain pattern and chronic primary pain category positively influence IV ketamine therapy response, while a history of previous analgesic interventions is associated with treatment failure. | |
| Age and history of neuromodulation therapy were found to negatively impact the clinical response to IV ketamine therapy in patients with treatment-resistant depression. Staging models were not predictive. |
Related Questions
What are the physiological factors that affect the response of medications in the human body?5 answersPhysiological factors significantly influence drug responses in the human body. These factors include lifestyle changes like exercise and diet, age, dose-time correlation, exposure time, nutritional status, gender, sex, and hormonal conditions. Drug-metabolizing enzymes (DMEs) play a crucial role in drug detoxification, affected by species, genetics, age, gender, and hormones. The gastrointestinal tract (GIT) also impacts drug metabolism through factors like pH, passage time, and solubilizers. These physiological parameters control drug metabolism, absorption, distribution, and excretion, ultimately affecting drug efficacy and toxicity. Understanding these factors is essential for predicting and managing drug interactions and toxicities in clinical settings.
What are the specific physiopathological cardiac factors that influence the response to drugs?5 answersSpecific physiopathological cardiac factors that influence the response to drugs include the potential cardiotoxic effects of various drug categories like antineoplastic agents, psychotropic medications, heavy metals, and antiarrhythmic agents, which can individually cause detrimental changes to the heart's function. Additionally, the diversity in tissue response to vasoactive substances highlights the importance of in vivo studies to evaluate morphological effects, with factors like animal species, age, sex, and hormonal conditions impacting the severity and distribution of drug-induced cardiac lesions. Furthermore, utilizing human induced pluripotent stem cell-derived cardiomyocytes allows for the assessment of how compounds interact with ion channels affecting the cardiac action potential, with techniques like voltage-sensitive dyes and multi-electrode arrays aiding in accurately estimating the impact of novel drugs on cardiac electrical function.
What are the factors that contribute to the non-response to HIV treatment?5 answersNon-response to HIV treatment can be influenced by various factors. Factors such as individual characteristics, social-cultural factors, social-economic factors, environmental factors, and healthcare provider factors have been found to contribute to non-adherence to antiretroviral therapy (ART) treatment among HIV patients. Younger age, minority background, less severe illness, and lower perceived social support have been identified as predictors of non-adherence to medical appointments. Loneliness in marital status, revival church religion, low level of knowledge of ART principles, and lack of knowledge of ART duration have also been associated with non-compliance to ART. History of opportunistic infection and depression have been found to be predictors of non-adherence to ART. Addressing adherence issues in pre-ART counseling and involving family and social support have been recommended to improve adherence to ART.
What are predictors of SSRI treatment response?5 answersThe predictors of SSRI treatment response include non-verbal memory and organizational abilities in OCD patients. Functional magnetic resonance imaging (fMRI) during the perception of emotional stimuli can also reveal regional brain function that serves as predictors of response to SSRI treatment in patients with major depressive disorder (MDD). Insulin resistance, psychiatric comorbidity, and metabolic parameters are associated with treatment response to SNRI in fibromyalgia (FM) patients. Cognitive vulnerability factors such as performance-oriented dysfunctional attitudes, anxiety sensitivity, and obsessive beliefs can predict treatment response in patients with MDD, panic disorder, and obsessive-compulsive disorder (OCD). Socioeconomic status (SES) and dose of SSRI medication can also predict treatment outcome, with higher SES and appropriate dosage leading to better remission rates.
How does ketamine affect eeg rhythms?5 answersKetamine affects EEG rhythms by inducing changes in brain activity. At low doses, ketamine causes low amplitude paroxysmal fast activity (PFA) and slow waves, while higher doses lead to burst suppression (BS) patterns and unconsciousness. These initial changes occur in the occipital lobes before spreading to other regions of the brain. Ketamine can also lower seizure thresholds and increase interictal epileptiform discharges (IEDs) in individuals predisposed to epilepsy. Unlike propofol, another anesthetic, ketamine does not increase the power of frontal alpha rhythms but reduces frontal-parietal and frontal-to-parietal connectivity in the alpha bandwidth. Ketamine also affects spindle alpha waves, shifting their frequencies to higher values. In terms of sensory gating and oscillatory characteristics, ketamine attenuates theta frequency band activity and disrupts poststimulus theta power reduction. These findings suggest that ketamine's effects on EEG rhythms involve modulation of NMDA receptors and may have implications for conditions like epilepsy and schizophrenia.
What are the factors that influence the response to information?4 answersFactors that influence the response to information include the presentation of information, internal and external factors, psychological and cultural differences, and actions taken by instructors and library staff.