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What are the specific optical properties that distinguish breast cancer cells from healthy cells? 

Hypoxia (environmental)
Hyperspectral imaging
Femtosecond
Kerr effect
Ultrashort pulse
Best insight from top research papers

Breast cancer cells can be distinguished from healthy cells based on specific optical properties. Various studies have highlighted key optical characteristics for this differentiation. The optical Kerr effect has been proposed as a method to detect different grades of breast cancer by tracking electronic and molecular processes, showcasing changes in tissue conductivity based on cancer grade . Additionally, the critical angle of malignant tissue, as determined by the Fresnel equation, differs from that of healthy tissue, providing a distinctive optical parameter for diagnosing lesion tissues . Furthermore, the use of hyperspectral imaging has identified optimal spectral bands in the visible and near-infrared spectra that can differentiate between normal and tumor tissues, with high accuracy, sensitivity, and specificity rates . These optical properties offer promising avenues for non-invasive and effective diagnostic methods for breast cancer.

Answers from top 5 papers

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Papers (5)Insight
Open access•Journal Article
Enhancing Contrast in Optical Imaging of Cancer tissues and Study the Spectral Properties of Methylene Blue
Sadia Malik, Hafeez Ullah, Farah Andleeb, Zahida Batool, Alia Nazir, Ghulam Gilanie, M. Nisa, A. Rashid 
17 Sep 2021-Acta Microscopica
Breast cancer cells exhibit higher accumulation of Methylene Blue in mitochondria, leading to increased fluorescence, distinguishing them from healthy cells based on optical imaging and spectral properties.
Journal Article•DOI
Optical monitoring and treatment of breast cancer by a tumor hypoxia-activated multi-functional fluorescent sensor
Allan Kellehear, Shahin Ahmadi 
01 Feb 2023
The near-infrared multifunctional azo-derivative, L4OD, targets hypoxic tumor environments, releasing fluorescent signals upon reacting with cytochrome P450 reductase, enabling optical detection and breast cancer tumor growth inhibition.
Journal Article•DOI
Mathematical and computational modeling for the determination of optical parameters of breast cancer cell.
Shadeeb Hossain, Shamera Hossain 
29 Jul 2021-Electromagnetic Biology and Medicine
The critical angle and reflectance properties differentiate breast cancer cells from healthy cells, aiding in non-invasive optical diagnosis with potential for AI integration in disease progression monitoring.
Open access•Journal Article•DOI
Malignant versus normal breast tissue: Optical differentiation exploiting hyperspectral imaging system
Mohamed Hisham Aref, Ibrahim H. Aboughaleb, Abdallah Abdelkader Hussein, Ayman Mohammed Farag, Sara Abd El-Ghaffar, Yasser H. El-Sharkawy 
21 Mar 2023
Specific optical properties that distinguish breast cancer cells from healthy cells include optimal spectral bands of 600-680 nm and 750-960 nm for reflectance, and 560-590 nm and 760-810 nm for transmission.
Open access•Posted Content•DOI
Femtosecond Optical Kerr Gates in Cancerous Breast Tissue for a New Optical Biopsy Method
Henry J. Meyer, Sandra Mamani, Zhi Li, Lingyan Shi, Robert R. Alfano 
10 May 2023-Research square
The variances in ultrafast plasma Kerr responses related to dielectric relaxation distinguish breast cancer cells by showing significant changes in tissue conductivity depending on the cancer grade.

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