What are the underlying molecular mechanisms of photobio modulation in regulating biofilm formation in wounds?
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Photobiomodulation (PBM) therapy, a low-dose biophotonics treatment, has been shown to improve wound healing, including diabetic wounds. The molecular mechanisms underlying PBM-induced regulation of biofilm formation in wounds involve several pathways. PBM activates mitochondrial cytochrome C oxidase, photosensitive cell membrane receptors, and transport channels, leading to the activation of latent TGF-β1 and subsequent wound healing . In addition, the blue light sensing A (BlsA) photoreceptor protein in the opportunistic pathogen A. baumannii plays a role in regulating biofilm formation and iron uptake through interactions with transcription factors such as BfmR and Fur . Furthermore, light exposure has been found to inhibit biofilm matrix production in Pseudomonas aeruginosa, a leading cause of biofilm-based bacterial infections, through the modulation of cyclic di-GMP levels and the activity of c-di-GMP phosphodiesterases . These findings highlight the diverse molecular mechanisms by which photobiomodulation can regulate biofilm formation in wounds.
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7 Citations | The provided paper does not discuss the molecular mechanisms of photobiomodulation in regulating biofilm formation in wounds. |
17 Citations | The provided paper does not specifically discuss the molecular mechanisms of photobiomodulation in regulating biofilm formation in wounds. |
| The provided paper does not discuss the underlying molecular mechanisms of photobiomodulation in regulating biofilm formation in wounds. | |
| The provided paper does not specifically discuss the underlying molecular mechanisms of photobiomodulation in regulating biofilm formation in wounds. | |
13 Citations | The provided paper does not specifically discuss the molecular mechanisms of photobio modulation in regulating biofilm formation in wounds. |
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