What caused hypoalbuminemia?
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Hypoalbuminemia can be caused by various factors such as acute liver damage, oxidative burst, viral-albumin binding, dysregulated immunological responses, and interference of the viral genome in host cells, leading to organ failure and mortality . Additionally, hypoalbuminemia is associated with inflammation, where increased capillary permeability due to inflammation causes serum albumin to escape, expanding the interstitial space and reducing total albumin mass despite increased synthesis rates . In the context of COVID-19, severe cases have shown hypoalbuminemia, which is linked to the downregulation of albumin synthesis in the liver due to cytokine interactions during the viral-induced cytokine storm, exacerbating hypovolemia and shock in critical care settings . Malnutrition and preoperative conditions like low serum albumin levels are also significant predictors of hypoalbuminemia and postoperative complications .
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457 Citations | Inflammation increases capillary permeability, leading to serum albumin escape into interstitial space, shortening albumin half-life, and decreasing total mass, causing hypoalbuminemia. |
| Assay interference caused by laboratory artifact led to severe hypoalbuminemia in the case presented, highlighting the potential for discord between biomarkers and clinical status. | |
| Hypoalbuminemia in COVID-19 is caused by acute liver damage, oxidative burst, viral-albumin binding, dysregulated immune responses, and viral interference in host cells, leading to organ failure and mortality. | |
14 Apr 2022 | Malnutrition is a primary cause of hypoalbuminemia, defined as serum albumin levels below 35 g/L, as indicated in the narrative review on total joint arthroplasties. |
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