What chemical modifications in biomaterials can enhance sequestering proteins?
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Chemical modifications in biomaterials can enhance sequestering proteins by altering the surface properties to control protein adsorption. Proteins can be chemically modified to improve their loading in nanocarriers, enhancing protein retention and enzymatic activity. Surface-modified silica materials obtained via sol-gel routes can be used as solid supports for protein immobilization, ensuring the proteins retain their bioactivity. Additionally, surface modification of vascular grafts with specific peptides and genes can promote selective endothelial cell recruitment and functional endothelialization, improving the long-term patency of artificial vascular grafts. These chemical modifications offer a way to manipulate protein adsorption, enhance protein loading, and ultimately improve the performance and biocompatibility of biomaterials for various biomedical applications.
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| Papers (4) | Insight |
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100 Citations | Chemical modifications like amino, thiol, and hydroxyl groups on biomaterial surfaces enhance protein sequestering by regulating interactions through forces like Van der Waals, hydrophilic, and steric hindrance. |
2 Citations | Amino acid conjugated self-assembled molecules (SAMs) on SiO2 surfaces can enhance protein sequestering by controlling protein adsorption selectivity, potentially improving biomaterial biocompatibility for various biomedical applications. |
7 Citations | Chemical modification of protein surfaces with malonic acid moieties enhances protein loading in chitosan nanoparticles, improving sequestering capabilities for biotechnological and biomedical applications. |
01 Mar 2021 5 Citations | Chemical modifications like inserting motifs can enhance protein crosslinking and attachment of biochemical groups, improving sequestering properties in biomaterials, as discussed in the paper. |
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