What gene expression is regulated by calcium in beta cell?
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Calcium signaling plays a crucial role in regulating gene expression in beta cells. Studies have shown that genes such as Mafa, CaMKIV, neuroendocrine convertase1 (Pcsk1), nitric oxide synthase-1 (NOS-1) , Ppy, S100a6, S100a4, Ascl1, Aldh1a3 , and GJD2 are influenced by changes in intracellular calcium levels. Specifically, calcium dynamics impact the expression of transcription factors, insulin-related genes, markers of beta cell dedifferentiation, and genes associated with beta cell failure. These findings highlight the intricate relationship between calcium signaling and gene regulation in beta cells, shedding light on how disruptions in this process can contribute to conditions like diabetes.
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| Papers (5) | Insight |
|---|---|
| Calcium signaling in beta cells regulates the expression of insulin transcription factor Mafa, CaMKIV, neuroendocrine convertase1 (Pcsk1), and nitric oxide synthase-1 (NOS-1). | |
| Genes like S100a6, S100a4, and Ascl1 are regulated by calcium in beta cells, indicating their association with membrane depolarization and Ca2+ influx in beta-cell identity disruption. | |
| Calcium regulates NFAT activation and downstream gene transcription in beta cells, impacting genes involved in beta-cell function, proliferation, and insulin granule biogenesis. | |
| CaV1.2 gene expression is not regulated by calcium in beta cells; instead, lipotoxicity-induced degradation of CaV1.2 protein affects insulin secretion in pancreatic β-cells. | |
2 Citations | Calcium-regulated gene expression in beta cells includes NFAT targets, intermediate early genes (IEGs), and GJD2, influencing islet function and gap junction communication. |
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