V
Veit Flockerzi
Researcher at Saarland University
Publications - 215
Citations - 19622
Veit Flockerzi is an academic researcher from Saarland University. The author has contributed to research in topics: Transient receptor potential channel & Voltage-dependent calcium channel. The author has an hindex of 71, co-authored 202 publications receiving 18236 citations. Previous affiliations of Veit Flockerzi include Akita University & Technische Universität München.
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Journal ArticleDOI
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels
TL;DR: Kinetic analysis of gating at different temperatures indicates that temperature sensitivity in TRPM8 and TRPV1 arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
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Primary structure and functional expression from complementary dna of a brain calcium channel
Yasuo Mori,Thomas Friedrich,Man Suk Kim,Atsushi Mikami,Junichi Nakai,Peter Ruth,Eva Bosse,Franz Hofmann,Veit Flockerzi,Teiichi Furuichi,Katsuhiko Mikoshiba,Katsuhiko Mikoshiba,Keiji Imoto,Tsutomu Tanabe,Shosaku Numa +14 more
TL;DR: The primary structure of a voltage-dependent cal-cium channel from rabbit brain has been deduced by cloning and sequencing the complementary DNA and it is suggested that it is expressed predominantly in cerebellar Purkinje cells and granule cells.
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The TRP channels, a remarkably functional family.
TL;DR: TRP cation channels display an extraordinary assortment of selectivities and activation mechanisms, some of which represent previously unrecognized modes for regulating ion channels.
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A Unified Nomenclature for the Superfamily of TRP Cation Channels
Craig Montell,Lutz Birnbaumer,Veit Flockerzi,René J. M. Bindels,Elspeth A. Bruford,Michael J. Caterina,David E. Clapham,Christian Harteneck,Stefan Heller,David Julius,Itaru Kojima,Yasuo Mori,Reinhold Penner,Dirk Prawitt,Andrew M. Scharenberg,Günter Schultz,Nobuyoshi Shimizu,Michael X. Zhu +17 more
TL;DR: The current effort to unify the TRP nomenclature focuses on three subfamilies that bear significant similarities to the founding member of this superfamily, Drosophila TRP, and which include highly related members in worms, flies, mice, and humans.
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Activation of TRPV4 Channels (hVRL-2/mTRP12) by Phorbol Derivatives
Hiroyuki Watanabe,John B. Davis,Darren Smart,Jeff C. Jerman,Graham D Smith,Phil Hayes,Joris Vriens,William Cairns,Ullrich Wissenbach,Jean Prenen,Veit Flockerzi,Guy Droogmans,Christopher D. Benham,Bernd Nilius +13 more
TL;DR: It is concluded that the phorbol derivatives activate TRPV4 (VR-OAC, VRL-2, OTRPC4, TRP12) independently from protein kinase C, in a manner consistent with direct agonist gating of the channel.