What is a target organ?
Best insight from top research papers
A target organ is an organ where the major toxicity is induced by chemicals. Various organs such as the liver, kidney, lungs, heart, reproductive systems, and more can act as target organs, playing crucial roles in bodily functions. In environmental and occupational health, target organs for toxic exposures are commonly the lungs, kidney, and liver. The liver, for instance, is frequently a target organ due to its vulnerability to damage from toxic substances, especially in experimental animal studies. Understanding why certain chemicals exhibit "organ selectivity" in inducing toxicity is a key question raised by the susceptibility of organs like the liver and kidney to xenobiotic toxicity. Target organs are pivotal in toxicology studies as they help identify the specific organs affected by harmful substances.
Answers from top 5 papers
More filters
| Papers (5) | Insight |
|---|---|
| A target organ is a specific organ in the body, such as the liver, kidney, lungs, or heart, that is susceptible to damage from exposure to toxic chemicals or substances. | |
| The liver is a target organ for toxicity due to its metabolic capabilities and vulnerability to damage from toxic compounds, particularly highlighted by carbon tetrachloride hepatotoxicity. | |
| A target organ is a specific organ in the body that is vulnerable to the effects of toxic exposures, such as the lungs, kidneys, and liver in environmental and occupational health. | |
| A target organ is a specific organ susceptible to toxicity, such as the kidney, heart, lung, male and female reproductive systems, eye, inner ear, and endocrine pancreas, as discussed in the paper. | |
| A target organ is where major toxicity occurs due to chemicals. This chapter introduces general organ toxicity, leading to detailed coverage of specific organ toxicity in subsequent chapters. |
Related Questions
How do researchers define the term "target population"?5 answersResearchers define the term "target population" as the specific group of individuals to whom the results of a study are intended to be applied or generalized. This group is identified based on the research questions being asked and plays a crucial role in achieving the goals of the research project by guiding the sampling process. In biomedical research, collaboration between researchers and biostatisticians is essential to determine the relevant parameters of the population related to the research questions. Understanding the target population is vital for designing representative clinical trials, as seen in the case of antidiabetic drug trials, where different target populations significantly impacted trial representativeness based on eligibility criteria. The target population's characteristics and distribution are key factors in ensuring the external validity of study results.
Why is blood target organ?4 answersBlood is considered a target organ because it plays a crucial role in delivering oxygen and nutrients to various organs in the body. It supplies the necessary resources for the proper functioning of organs such as the heart, brain, kidneys, and others. Additionally, blood vessels are structurally and functionally heterogeneous, meaning that they have different characteristics and functions depending on the organ they supply. The blood vessels of different organs have specific arterial blood flow patterns, which can influence the frequency of metastatic involvement and the development of diseases such as atherosclerosis and thrombosis. Therefore, understanding the role of blood vessels and their specific functions in different organs is essential for studying diseases, developing targeted therapies, and maintaining overall organ health.
Whats the best nich to target3 answersThe best NICH to target is youth with type 1 diabetes (T1D) and high social risk. This population experiences health disparities and acute complications. The NICH program has been shown to improve health outcomes, reduce complications, and lower medical costs for youth with T1D. It has been found to significantly reduce hospitalizations, emergency department visits, and costs per youth, with the greatest impact observed in the second year of follow-up. Additionally, personalized text messages related to diabetes and adherence have been associated with improvements in youth health outcomes within the NICH program. Therefore, targeting youth with T1D and high social risk through the NICH program can effectively address their unique needs and improve their health outcomes.
Who introduced the concept of target organ in toxicology?5 answersThe concept of target organ in toxicology was introduced by Curtis D. Klaassen and John B. Watkins.
What is a target population?1 answersA target population refers to a specific group of individuals or entities that a particular policy, medicine, or invention is intended to address or benefit. It can include different populations that may partially overlap, such as those evaluated in clinical trials, those for whom a medicine provides actual benefit, or those for whom a drug provides an improvement of the actual benefit. The concept of target populations is important in public policy as it helps shape the construction of policies. The characteristics and perceptions of target populations can influence the design and implementation of policies, with politically weak populations often facing harsh and punitive measures. In the context of inventions, a target population calculation method is used to improve population calculation efficiency while ensuring accurate logic. Additionally, target populations can be etched into a substrate with asymmetry to distinguish and determine their characteristics.
What is a target customer?5 answersA target customer refers to the specific group of individuals or customers that a business aims to attract and serve. Understanding the target market and their needs is crucial for businesses when developing new products or services, implementing marketing plans, and selecting appropriate sales outlets. Target marketing is a marketing strategy that analyzes the preferences of existing customers and develops goods and services that align with those preferences. By implementing personalized target marketing, companies can deliver more effective and efficient marketing campaigns that maximize customer satisfaction. Target customers can be classified based on their characteristics and behaviors, and this classification can be used to tailor marketing efforts and provide personalized services. Overall, identifying and understanding the target customer is essential for businesses to effectively cater to their needs, design products, and implement successful marketing strategies.