What is aldosterone escape?
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Aldosterone escape refers to two distinct phenomena. In primary hyperaldosteronism, aldosterone escape is the escape from the sodium-retaining effects of excess mineralocorticoids or aldosterone, resulting in volume and/or pressure natriuresis . On the other hand, in patients with heart failure or diabetes receiving ACE inhibitor therapy, aldosterone escape refers to the inability of ACE inhibitors to reliably suppress aldosterone release, leading to increased salt and water retention . The term "refractory hyperaldosteronism" has been proposed to describe the failure of ACE inhibitor or angiotensin receptor blocker therapy to suppress aldosterone release, taking into account factors other than angiotensin II that influence aldosterone release, such as plasma potassium levels .
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Open access•Journal Article 6 Citations | The paper discusses two opposite phenomena referred to as "aldosterone escape." One is the escape from the sodium-retaining effects of excess aldosterone, while the other is the inability of ACE inhibitor therapy to suppress aldosterone release. |
| Aldosterone escape refers to the phenomenon where aldosterone levels return to or exceed baseline levels despite the use of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) in the treatment of hypertension. | |
58 Citations | Aldosterone escape refers to the excretion of sodium (Na) during high Na intake despite increased levels of mineralocorticoids. |
| The provided paper does not specifically mention "aldosterone escape." |
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