T
Timo Rieg
Researcher at University of South Florida
Publications - 80
Citations - 5435
Timo Rieg is an academic researcher from University of South Florida. The author has contributed to research in topics: Kidney & Internal medicine. The author has an hindex of 33, co-authored 66 publications receiving 4554 citations. Previous affiliations of Timo Rieg include University of California, San Diego & University of Tübingen.
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Journal ArticleDOI
Na+-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose-Absorption and Glucose-Dependent Incretin Secretion
Valentin Gorboulev,Annette Schürmann,Volker Vallon,Helmut Kipp,Alexander Jaschke,Dirk Klessen,Alexandra Friedrich,Stephan Scherneck,Timo Rieg,Robyn Cunard,Maike Veyhl-Wichmann,Aruna Srinivasan,Daniela Balen,Davorka Breljak,Rexhep Rexhepaj,Helen E. Parker,Fiona M. Gribble,Frank Reimann,Florian Lang,Stefan Wiese,Ivan Sabolić,Michael Sendtner,Hermann Koepsell +22 more
TL;DR: In this article, the role of SGLT1 in small intestine and kidney glucose absorption was investigated in Sglt1(-/-) mice, which developed a glucose-galactose malabsorption syndrome.
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SGLT2 Mediates Glucose Reabsorption in the Early Proximal Tubule
Volker Vallon,Kenneth A. Platt,Robyn Cunard,Jana Schroth,Jean M. Whaley,Scott C. Thomson,Hermann Koepsell,Timo Rieg +7 more
TL;DR: It is demonstrated that SGLT2 mediates glucose re absorption in the early proximal tubule and most of the glucose reabsorption by the kidney, overall, which mimics and explains the glucosuric phenotype of individuals carrying SLC5A2 mutations.
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SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice.
Volker Vallon,Volker Vallon,Maria Gerasimova,Michael Rose,Takahiro Masuda,Takahiro Masuda,Joseph Satriano,Joseph Satriano,Eric Mayoux,Hermann Koepsell,Scott C. Thomson,Scott C. Thomson,Timo Rieg,Timo Rieg +13 more
TL;DR: It is proposed that SGLT2 inhibition can lower GFR independent of reducing BG (consistent with the tubular hypothesis of diabetic glomerular hyperfiltration), while attenuation of albuminuria, kidney growth, and inflammation in the early diabetic kidney may mostly be secondary to lower BG.
Journal ArticleDOI
Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus
Volker Vallon,Volker Vallon,Michael Rose,Maria Gerasimova,Joseph Satriano,Joseph Satriano,Kenneth A. Platt,Hermann Koepsell,Robyn Cunard,Robyn Cunard,Kumar Sharma,Kumar Sharma,Scott C. Thomson,Scott C. Thomson,Timo Rieg,Timo Rieg +15 more
TL;DR: The results indicate that SGLT2 is a determinant of hyperglycemia and glomerular hyperfiltration in STZ-induced diabetes mellitus but is not critical for the induction of renal growth and markers of renal injury, inflammation, and fibrosis.
Journal ArticleDOI
Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat
Scott C. Thomson,Timo Rieg,Cynthia M. Miracle,Hadi Mansoury,Jean M. Whaley,Volker Vallon,Prabhleen Singh +6 more
TL;DR: TGF contributes to long-term fluid and salt balance by mediating a persistent decline in SNGFR as the kidney adapts to a sustained decrease in Jprox.