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What is Ciclesonide? 

Spironolactone
Acne
Asymptomatic
Antiandrogen
Cytokine storm
Best insight from top research papers

Ciclesonide is an inhaled corticosteroid that has been repurposed as a treatment for COVID-19 patients. It has been shown to block the production of certain cytokines and inhibit the replication of coronaviruses . In a study conducted in Sweden, ciclesonide was found to have no significant effect on the duration of oxygen therapy in COVID-19 patients . However, another study conducted in Japan found that ciclesonide actually worsened pneumonia in patients with mild or asymptomatic COVID-19 . In a study involving horses with severe equine asthma, ciclesonide inhalation was found to effectively reduce the severity of clinical signs and was well tolerated . Overall, ciclesonide is an inhaled corticosteroid that has shown potential as a treatment for COVID-19 and severe equine asthma, but its efficacy and safety may vary depending on the specific condition and patient population.

Answers from top 5 papers

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Papers (5)Insight
Journal Article•DOI
Clascoterone for treatment of acne.
Cyriac Manjaly, Jeremy Martinez, John S. Barbieri, Arash Mostaghimi 
01 Feb 2023-Drugs of Today
The provided paper does not mention anything about Ciclesonide.
Open access•Journal Article•DOI
The Synergistic Inhibition of Coronavirus Replication and Induced Cytokine Production by Ciclesonide and the Tylophorine-Based Compound Dbq33b
Yue-Zhi Lee, Hsing-Yu Hsu, Cheng-Wei Yang, Yi-Ling Lin, Sui-Yuan Chang, Ruey-Bing Yang, Jiangli Liang, Tai Ling Chao, Chun-Che Liao, Han Chieh Kao, Jang Yang Chang, Huey-Kang Sytwu, Chiung-Tong Chen, Shiow Ju Lee 
01 Jul 2022-Pharmaceutics
1 Citations
Ciclesonide is an inhaled corticosteroid used to treat asthma and has been repurposed as a treatment for mildly ill COVID-19 patients.
Open access•Journal Article•DOI
Inhaled ciclesonide in adults hospitalised with COVID-19: a randomised controlled open-label trial (HALT COVID-19)
Daniel Brodin, Per Tornhammar, Peter Ueda, Anders Krifors, Eli Westerlund, Simon Athlin, Sandra Wojt, Olof Elvstam, Anca Neumann, Arsim Elshani, Julia Giesecke, Jens Edvardsson-Källkvist, Sayam Bunpuckdee, Christian Unge, Martin Larsson, Björn Johansson, Johan Ljungberg, Jonas Lindell, Johan Hansson, Ola Blennow, Daniel P. Andersson 
01 Feb 2023-BMJ Open
Ciclesonide is a medication that was tested in the study. The paper does not provide further information about what ciclesonide is or how it is used.
Open access•Journal Article•DOI
Impact of inhaled ciclesonide on asymptomatic or mild COVID-19: A randomized trial.
Junko Terada-Hirashima, Manabu Suzuki, Yoshie Tsujimoto, Yoichiro Hamamoto, Yukari Uemura, Kenji Tsushima, Hideki Inoue, Shigeru Komatsu, Zenya Saito, Ryuta Tsuzuki, Masaki Okamoto, Yasuo To, Kyoji Moriya, Sadako Yoshizawa, Masahide Tanaka, T. Muto, Ayako Mikami, Jin Takasaki, Shinyu Izumi, Norio Ohmagari, Masayuki Hojo, Wataru Sugiura, Haruhito Sugiyama 
26 Oct 2022-Drug discoveries and therapeutics
3 Citations
Ciclesonide is a medication that was used in this study to treat mild or asymptomatic COVID-19 patients.
Open access•Journal Article•DOI
Inhaled ciclesonide is efficacious and well tolerated in the treatment of severe equine asthma in a large prospective European clinical trial.
Robert Pirie, Hanns-Walter Mueller, Odilo Engel, Balazs Albrecht, Marcella von Salis-Soglio 
01 Nov 2021-Equine Veterinary Journal
4 Citations
Ciclesonide is a glucocorticoid prodrug that is used as an inhaled treatment for severe equine asthma.

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