What is diference between ILC1-like IEL and ILC3-like IEL in human?
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ILC1-like IEL and ILC3-like IEL in humans have distinct characteristics. ILC1-like IELs express the transcription factor T-bet and secrete IFN-γ and TNF-α, which allows them to establish immune responses and directly kill target cells ^[Taggenbrock, van Gisbergen]. On the other hand, ILC3-like IELs express RORγt and secrete IL-17 and IL-22 ^[Leupold, Wirtz]. These ILC3-like IELs are primarily located at the periphery of lymphocytic infiltrates and are inversely correlated with the surface of T/B lymphocyte infiltrates ^[Kawka et al.]. They are more abundant in smaller infiltrates and in recently diagnosed patients with primary Sjögren’s syndrome (pSS) ^[Kawka et al.]. In addition, ILC3-like IELs are involved in the development of T and B lymphocyte infiltrates in the early stages of pSS ^[Kawka et al.]. Overall, the difference between ILC1-like IELs and ILC3-like IELs lies in their transcription factor expression, cytokine secretion, and their role in immune responses and tissue homeostasis.
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| The provided paper does not mention ILC1-like IEL or ILC3-like IEL in humans. |
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