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What is in lactobacillus supernatant that could have an inhibitory effect on fungal biofilms?

Candida tropicalis

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Lactobacillus supernatants contain metabolites that exhibit inhibitory effects on fungal biofilms. These metabolites include lactic acid and other exometabolites secreted by Lactobacillus strains. The inhibitory activity of lactate production was found to be essential in suppressing preformed biofilms and hyphal elongation of Candida albicans, while hydrogen peroxide was not always necessary for this effect. Additionally, the supernatants of Lactobacillus strains were shown to significantly inhibit biofilm formation and adhesion of Candida species to epithelial cells, indicating a multifaceted approach to combating fungal biofilms. These findings suggest that the metabolites present in Lactobacillus supernatants play a crucial role in inhibiting fungal biofilm formation, providing a potential alternative to traditional antifungal agents.

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Open access•Journal Article•DOI Vaginal Lactobacillus Impair Candida Dimorphic Switching and Biofilm Formation Carola Eleonora Parolin, Vanessa Croatti, Barbara Giordani, Beatrice Vitali - Show less +3 more 01 Oct 2022-Microorganisms 3 Citations	Lactobacillus supernatants contain compounds inhibiting fungal biofilms, possibly not solely due to acidity, suggesting the presence of other metabolites like bacteriocins and biosurfactants.
Open access•Posted Content•DOI Inhibitory Effects of Vaginal Lactobacilli on<em> Candida albicans </em>Growth, Hyphal Formation, Biofilm Development, and Epithelial Cell Adhesion 27 Sep 2022	Lactobacillus supernatant contains lactic acid and hydrogen peroxide, with lactic acid being essential to suppress Candida biofilms and hyphal formation, while hydrogen peroxide is not always necessary.
Open access•Journal Article•DOI Inhibitory effects of vaginal Lactobacilli on Candida albicans growth, hyphal formation, biofilm development, and epithelial cell adhesion Tomonori Takano, Hayami Kudo, Shuhei Eguchi, Asami Matsumoto, Kentaro Oka, Yukitaka Yamasaki, Motomichi Takahashi, Takuro Koshikawa, Hiromu Takemura, Yuka Yamagishi, Hiroshige Mikamo, Hiroyuki Kunishima - Show less +11 more 02 May 2023-Frontiers in Cellular and Infection Microbiology	Lactobacillus supernatant contains lactate and hydrogen peroxide, which inhibit Candida albicans biofilm formation, growth, hyphal development, and epithelial cell adhesion, contributing to antifungal effects.
Open access•Posted Content•DOI Inhibitory effect of lactobacilli supernatants on biofilm and filamentation of C. albicans, C. tropicalis, and C. parapsilosis Yeuklan Poon, Mamie Hui - Show less +1 more 26 Nov 2022-bioRxiv 1 Citations	Lactobacillus supernatants contain exometabolites, possibly other than lactic acid, that inhibit fungal biofilms by affecting filamentation and gene expression in Candida species like C. albicans and C. tropicalis.
Open access•Journal Article•DOI Inhibitory effect of lactobacilli supernatants on biofilm and filamentation of Candida albicans, Candida tropicalis, and Candida parapsilosis Yeuklan Poon, Mamie Hui - Show less +1 more 13 Feb 2023-Frontiers in Microbiology	Lactobacillus supernatants contain exometabolites, possibly other than lactic acid, that inhibit fungal biofilms by affecting filamentation and gene expression in Candida species like C. albicans and C. tropicalis.

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