scispace - formally typeset
Search or ask a question

What is known on fatty metaplasia in chronic myocardial infarction and arrhythmias? 


Best insight from top research papers

Fatty metaplasia in chronic myocardial infarction is a common finding that can alter the electroconductivity of the myocardium and contribute to the development of arrhythmias . Lipomatous metaplasia, characterized by the replacement of myocardium by fat, is often observed in scars associated with chronic ischemic heart disease . This fatty metaplasia can be detected using cardiac magnetic resonance (CMR) imaging techniques, such as late gadolinium enhancement (LGE) and fat-water separation imaging . Lipomatous metaplasia has been shown to be closely associated with prolonged local action potential duration and dispersion, which may facilitate the propensity of ventricular tachycardia (VT) circuit reentry . Additionally, myocardial regions with partial fatty infiltration can be detected using optimized steady-state free-precession (SSFP) cine imaging, allowing for consistent detection of myocardial fatty metaplasia in routine clinical CMR exams . Overall, fatty metaplasia in chronic myocardial infarction is an important factor in the pathogenesis of arrhythmias and can be effectively detected using various imaging techniques.

Answers from top 4 papers

More filters
Papers (4)Insight
The paper discusses the presence of fatty metaplasia in the left ventricle following myocardial infarction, but does not specifically mention its association with arrhythmias.
The provided paper does not specifically mention fatty metaplasia in chronic myocardial infarction and arrhythmias.
The provided paper does not provide information on fatty metaplasia in chronic myocardial infarction and arrhythmias.
Lipomatous metaplasia in chronic postmyocardial infarction scars is a common finding that can alter the electroconductivity of the myocardium, potentially leading to arrhythmogenesis.

Related Questions

Does cooking with certain fatty acids lead to increased risk of chronic diseases such as heart disease or obesity?5 answersCooking with certain fatty acids can indeed impact the risk of chronic diseases like heart disease and obesity. The choice of cooking oils plays a crucial role in health outcomes. Using oils with unbalanced ratios of omega-6 to omega-3 fatty acids can lead to inflammation, reduced immunity, heart disease, diabetes, and other health risks. Additionally, heating oils to high temperatures can increase trans fatty acid levels, which are associated with adverse health outcomes. Studies have shown that consuming butter and margarine is linked to higher total and cardiometabolic mortality, while canola oil and olive oil intake are associated with lower mortality rates. Therefore, replacing solid fats like butter with non-hydrogenated vegetable oils like canola oil, corn oil, or olive oil is recommended for better cardiometabolic health and longevity.
Pathophysiology of sudden cardiac death?4 answersSudden cardiac death (SCD) can occur in individuals with previously unrecognized heart disease, even in the absence of identifiable structural abnormalities. Certain discrete anatomic abnormalities, such as myocarditis, focal myocardial fibrosis, hypertrophy of Purkinje-like myocytes, and myocardial disarray, may be present in patients with normal mechanical cardiac function. The exact incidence of SCD is difficult to assess due to variability in the definition of "sudden" and the complexity of defining sudden death in cardiopathic patients. Not all cases of sudden cardiac death are solely due to myocardial ischemia or infarction, indicating the need for alternative pathophysiological mechanisms. The abnormal electrophysiology involved in potentially fatal arrhythmias is multifactorial, with predisposing electrophysiological factors interacting with triggering events and nonelectrophysiological abnormalities. The causes of SCD vary depending on the age of the individual, with primary electrical diseases, cardiomyopathies, myocarditis, and coronary anomalies being more prevalent in young people, while coronary atherosclerosis and degenerative valve diseases predominate in adult and elderly populations.
How does insulin resistance affect myocardial infarction?5 answersInsulin resistance has a significant impact on myocardial infarction (MI). It is associated with the development and progression of cardiovascular disease, leading to adverse prognostic effects on the course of MI. Insulin resistance is linked to the development of carbohydrate metabolism disorders, hyperglycemia, and reduced tissue sensitivity to insulin. These metabolic abnormalities contribute to the development of systolic-diastolic dysfunction of the myocardium in patients with acute coronary syndrome (MI). Insulin resistance, as measured by the Homeostasis Model Assessment for IR (HOMA-IR) and triglyceride glucose index (TyG), is associated with poor outcomes in patients with acute ST-segment elevation myocardial infarction (STEMI), including decreased ejection fraction and increased mortality. Furthermore, insulin resistance is also associated with nonalcoholic fatty liver disease (NAFLD), which worsens the prognosis of MI. The correlation between insulin resistance and liver fat content suggests that hepatic lipid content can serve as a non-invasive cardiovascular marker and may identify individuals with a worse outcome after MI. Multi-modality therapy, including medications such as dapagliflozin, has shown promise in improving insulin sensitivity and metabolic parameters in overweight and obese patients with MI, leading to improved carbohydrate metabolism and cardiac function.
Myocardial infraction?5 answersMyocardial infarction (MI) is a serious condition with limited data on long-term outcomes after coronary artery bypass grafting (CABG). The risk of mortality after MI among migrants compared to natives is mixed and limited, but migrants tend to have a higher risk of mortality in the long term due to factors such as lower socioeconomic status and limited access to healthcare resources. Engaging in social activities, particularly friendship or volunteer activities, is associated with better awareness of the warning symptoms of stroke and MI, which can lead to early hospital treatment and better prognosis. A composition containing Myristica fragrans ethyl acetate fraction shows potential for preventing or treating cardiac infarction by promoting heart contraction and relaxation. A specific biosensor has been developed for the sensitive determination of tissue plasminogen activator (tPA), which is important in the diagnosis and clinical research of cardiovascular diseases, including myocardial infarction.
What id epicardial fat mass association with heart failure?5 answersEpicardial fat mass is associated with heart failure (HF) and atrial fibrillation (AF). Studies have shown that epicardial fat thickness is related to HF with preserved ejection fraction (HFPEF). In patients with noncachectic HF, epicardial fat thickness is positively correlated with body mass index (BMI) and leptin levels, and negatively correlated with brain natriuretic peptide. Additionally, epicardial fat from rabbits with HF has been found to increase atrial arrhythmogenesis, contributing to higher atrial arrhythmia in obesity. Furthermore, the influence of epicardial fat on left ventricular (LV) diastolic function has been studied in patients after acute myocardial infarction, showing a significant association between LV diastolic dysfunction parameters and epicardial fat volume. These findings suggest that epicardial fat mass is associated with HF and can impact cardiac function and arrhythmogenesis.
What myocardial infraction parhophyscology from books?2 answersMyocardial infarction is a major health problem and a leading cause of morbidity and mortality worldwide. It is characterized by the death of myocardial cells due to prolonged ischemia. Risk factors for myocardial infarction include high blood pressure, smoking, diabetes, lack of exercise, obesity, depression, high blood cholesterol, poor diet, lifestyle, excessive alcohol intake, and family history. The pathophysiology of myocardial infarction involves inadequate myocardial oxygenation and the accumulation of anaerobic metabolites when myocardial oxygen demand exceeds supply. Perioperative myocardial infarction is a significant cause of morbidity and mortality in surgical patients, with over 50,000 cases occurring each year. Postoperative myocardial ischemia is more common than preoperative and intraoperative ischemia. Genetic polymorphisms have also been studied for their association with the risk of myocardial infarction..