What is Parkinson's disease pathophysiology?
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Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. The disease is primarily caused by the abnormal aggregation of α-synuclein, forming Lewy bodies. PD pathophysiology involves various factors such as oxidative stress, mitochondria dysfunction, endoplasmic reticulum stress, altered dopamine catabolism, and reduced neurotrophic factors, leading to apoptotic neuronal cell death. Additionally, exposure to environmental factors like the herbicide paraquat has been linked to PD pathogenesis, inducing PD-like features in laboratory models. Genetic variants also play a role in PD, affecting pathways related to endosomal, lysosomal, and mitochondrial dysfunction, all influenced by α-synuclein. Understanding these mechanisms is crucial for developing potential therapeutic targets for PD.
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| Papers (5) | Insight |
|---|---|
| Parkinson's disease pathophysiology involves dopaminergic neuron loss in the substantia nigra, α-synuclein aggregation, oxidative stress, mitochondrial dysfunction, ER stress, altered dopamine catabolism, and decreased neurotrophic factors leading to apoptosis. | |
| Parkinson's disease pathophysiology involves abnormal aggregation of α-synuclein, leading to Lewy Body formation and spread, causing neuronal damage and clinical symptoms in patients. | |
01 Jan 2023 | Parkinson's disease pathophysiology involves dopaminergic neuron degeneration, Lewy body formation with α-synuclein aggregation, mitochondrial dysfunction, oxidative stress, and neuroinflammation, which interact in a complex manner. |
62 Citations | Parkinson's disease pathophysiology involves substantia nigra degeneration, α-synuclein accumulation in Lewy bodies, and dysfunction in endosomal, lysosomal, and mitochondrial pathways, influenced by genetic and environmental factors. |
| Parkinson's disease pathophysiology involves neuronal loss due to protein aggregates, leading to apoptosis and degeneration. The slow progression complicates early detection, emphasizing the need for biomarkers. |
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