What is perhydrolysis?
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Perhydrolysis is a chemical process that involves the reaction of a compound with hydrogen peroxide to form a peracid. It can be used to synthesize hydroperoxy alcohols from epoxides using a catalyst consisting of phosphotungstic acid . Perhydrolysis can also be used to convert ketones, ketals, and epoxides into hydroperoxides with high chemoselectivity using a catalytic amount of MoO2(acac)2 . In the field of pharmaceutical analysis, perhydrolysis is used in spectrophotometry, fluorimetry, and voltammetry methods to enhance detectability of drugs such as antibiotics, esters, and peroxides . The molecular basis of perhydrolysis activity involves the formation of a hydrogen bond between the enzyme and hydrogen peroxide in the transition state, as observed in the X-ray structures of L29P PFE . Perhydrolysis can also be used to achieve the ring-opening of tertiary oxetanes and secondary oxetanes with different functional groups, under mild conditions .
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13 Citations | Perhydrolysis is a chemical reaction that involves the addition of hydrogen peroxide to a compound, resulting in the formation of a hydroperoxide. |
68 Citations | Perhydrolysis is the reversible formation of peracids from carboxylic acids and hydrogen peroxide. |
01 Jan 2017 6 Citations | Perhydrolysis is a reaction that involves the oxidation of drugs using peroxy acids or oxone to enhance detectability in pharmaceutical analysis. |
| Perhydrolysis is a process of synthesizing hydroperoxy alcohols by reacting epoxides with an aqueous solution of hydrogen peroxide in the presence of a catalyst. | |
8 Citations | Perhydrolysis is a chemical reaction in which a compound reacts with hydrogen peroxide to form a hydroperoxide. |
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