Search or ask a question

What is propargylpemoline?

Propentofylline

Best insight from top research papers

Propargylpemoline is not explicitly mentioned in the provided contexts. However, propargylamine derivatives, such as propentofylline, have shown significant potential in medicinal chemistry and drug discovery. Propargylamine is a versatile chemical moiety that serves as a key intermediate for synthesizing various bioactive compounds, including those used in the treatment of dementia. Its reactivity allows for the preparation of diverse derivatives, contributing to the development of therapeutic agents and chemical biology research. Additionally, propargylamine derivatives have been utilized in the synthesis of heterocycles like pyrroles and quinolones, showcasing their broad applications in medicinal chemistry. Although propargylpemoline specifically is not discussed, the information on propargylamine derivatives highlights their importance in drug discovery and potential therapeutic uses.

Answers from top 5 papers

PDF

Open Access

More filters

Papers (5)	Insight
Journal Article•DOI Propentofylline for dementia. Maria A Frampton, Richard J. Harvey, Vincent Kirchner - Show less +2 more 22 Apr 2003-Cochrane Database of Systematic Reviews 52 Citations	Not addressed in the paper.
Journal Article•DOI Propentofylline Stuart Noble, Antona J. Wagstaff - Show less +1 more 01 Sep 1997 6 Citations	Not addressed in the paper.
Open access•Journal Article•DOI New Strategy for the Synthesis of Morpholine Cores: Synthesis from N-Propargylamines Esmail Vessally, Akram Hosseinian, Ladan Edjlali, Mirzaagha Babazadeh, Rahim Hosseinzadeh-Khanmiri - Show less +4 more 01 Jun 2017-Iranian Journal of Chemistry & Chemical Engineering-international English Edition 19 Citations	Not addressed in the paper.
Journal Article•DOI Super Paramagnetic, MCM-41-Supported, Recyclable Copper-Complexed Dendrimer: A Novel Nanostructured Catalyst for Propargylamine Synthesis Under Solvent-Free Conditions Najmeh Gharibpour, Mohammad Abdollahi-Alibeik, Ali Moaddeli, Ali Moaddeli - Show less +3 more 03 Apr 2017 12 Citations	Not addressed in the paper.
Journal Article•DOI Propargylamine: an important moiety in drug discovery. Aitor Carneiro, Eugenio Uriarte, Fernanda Borges, Maria João Matos - Show less +3 more 21 Feb 2023-Future Medicinal Chemistry 1 Citations	Not addressed in the paper.

My columns

Related Questions

Whate is the asetylcholine esteras5 answersAcetylcholinesterase (AChE) is an enzyme crucial for cleaving the ester bond in acetylcholine, a neurotransmitter. It plays a significant role in various neurodegenerative disorders like Parkinson's, Alzheimer's, and Huntington's diseases. Inhibition of AChE by compounds like carbamate and organophosphorus insecticides can lead to adverse effects on the nervous system. While acetylcholine is a known neurotransmitter, there are indications that other related compounds may also act as transmitters at cholinergic nerve endings, emphasizing the need for further research on the role of AChE and related esters in physiological and pathological conditions. Additionally, the synthesis of novel phosphorus compounds with anticholinesterase activity highlights the importance of understanding the mechanisms and effects of these compounds on enzyme function.

What is 5-phenyl-2-(2-propynylamino)-2-oxazolin-4-one?5 answers5-phenyl-2-(2-propynylamino)-2-oxazolin-4-one is a compound that can be synthesized through various methods involving oxazoline derivatives. Different oxazoline compounds have been studied for their reactivity and applications. For instance, the dimerization of 2-aryl-4-methyloxazolin-5-ones is a main reaction observed in pure acetic anhydride conditions. Additionally, regioselective ring opening of oxazolones followed by Cu-catalyzed ring closure provides an efficient approach to various substituted oxazoles. Novel chiral auxiliaries like 5,5-diphenyl-2-phenylamino-2-oxazoline have been prepared and shown to be effective for asymmetric alkylation reactions. The molecular geometry and stability of oxazoline rings, even with substitutions, have also been studied. These insights can contribute to the understanding and synthesis of 5-phenyl-2-(2-propynylamino)-2-oxazolin-4-one.

What are the potential therapeutic effects of propolisin humans?4 answersPropolis, a natural product produced by bees, has shown potential therapeutic effects in humans. It possesses antiviral, antibacterial, antifungal, and antiparasitic activities, making it useful in the treatment of various diseases. Propolis has been investigated for its anticancer effects and has shown promising results. It also exhibits anti-inflammatory effects by reducing cellular levels of certain molecules involved in inflammation. In the context of respiratory tract diseases, propolis has been studied for its activity against viruses such as SARS-CoV-2, influenza viruses, and rhinoviruses. Additionally, propolis has been found to have antioxidant, anti-inflammatory, and immunomodulatory properties, making it beneficial in the treatment of chronic diseases such as metabolic syndrome and chronic kidney disease. Overall, propolis shows potential as a natural therapeutic agent for various conditions, and further research is needed to explore its full therapeutic potential.

What is the cyantraniliprole?5 answersCyantraniliprole is an insecticide that is widely used in the agriculture sector due to its low toxicity and fast degradation. It belongs to the anthranilic diamide class of insecticides and is effective against various pests, including Spodoptera litura and Cameraria ohridella. Cyantraniliprole can be applied to plants through different modes of application, such as translaminar and acropetal treatment. It has been found to have high affinity and selectivity towards cyantraniliprole, making it a suitable candidate for enzyme-based biosensors. The degradation products of cyantraniliprole have been identified, and their toxicological effects are being studied to assess potential environmental hazards. The US Environmental Protection Agency has raised concerns about the impact of cyantraniliprole on endangered species and has been working with pesticide manufacturers to develop measures to reduce exposure. Overall, cyantraniliprole is an important insecticide used in agriculture, but its potential impact on the environment and endangered species needs to be carefully evaluated.

What are the properties of propylene glycol?4 answersPropylene glycol is a water-soluble fluid that is safe for use in foods, drugs, and cosmetics. It has attractive properties as a solvent, humectant, or antifreeze, along with a low level of toxicity. It is used in many oral, topical, and intravenous pharmaceuticals. Propylene glycol is rapidly and extensively absorbed, distributed to tissues in proportion to body water, and eliminated from the body through metabolic clearance and renal excretion. It exists as an equal mixture of d and l stereoisomers, resulting in the formation of both d and l forms of lactate during metabolism. Propylene glycol has a low degree of toxicity in animals and humans, with high doses needed to elicit effects in acute toxicity studies. It does not pose concerns for reproductive or developmental toxicity or carcinogenesis in humans.

What is the role of the prophyrin ring in heme?4 answersThe porphyrin ring in heme plays a crucial role in its chemical properties and binding affinity for oxygen. Distortions in the porphyrin ring can significantly impact the binding affinity of heme for oxygen, with out-of-plane distortions decreasing the affinity and in-plane distortions either increasing or decreasing it. Among in-plane distortions, the breathing mode, which involves the symmetric compression-expansion of the porphyrin ring, strongly modulates the binding affinity. These findings suggest that certain classes of heme proteins may exploit in-plane distortions to modulate their ligand affinity. Additionally, the differences in heme side chains, such as propionyl, vinyl, and hydroxyfarnesylethyl groups, contribute to the diverse functions of heme. Overall, the porphyrin ring of heme is essential for its chemical properties and binding interactions, allowing heme to perform its various physiological roles.

See what other people are reading

How does plasma protein binding effect the distribution volume?

Plasma protein binding significantly impacts the distribution volume of a drug. The extent of protein binding in plasma or tissues plays a crucial role in controlling the volume of distribution, which in turn affects both hepatic and renal clearance. The volume of distribution (V) is determined by the fraction unbound in plasma (fu), the fraction unbound in tissue (fuT), the volume of tissue (VT), and the volume of plasma (VP). Additionally, modulation of plasma protein binding can be part of a viable strategy in drug discovery to optimize the effective half-life of drug candidates in humans, especially for acidic molecules. Understanding the relationship between plasma protein binding and drug distribution is essential for pharmacokinetic optimization and predicting the volume of distribution in humans.What is scoring function space?

The scoring function space is a concept that provides a systems-level approach to modeling and predicting the affinity of drug molecules in protein-ligand interactions. It allows for a holistic view of drug discovery by representing it as a relationship involving mathematical spaces, enhancing the understanding of receptor-drug interactions. This approach has been further extended to develop targeted-scoring functions, which are essential in creating machine-learning models to predict ligand-binding affinity. Additionally, the scoring function space has been utilized in generative modeling, where it generates fixed-length feature vectors based on the properties of the data generation process, leading to informative spaces known as "score spaces". This concept plays a crucial role in various domains, including drug discovery and computational biology, by enabling accurate predictions and classifications based on the underlying data structures.How does photostability compromise the use of luminescent europium beta-diketonate complexes?

Photostability plays a crucial role in the application of luminescent europium beta-diketonate complexes. These complexes are utilized in various fields like solid-state lighting and light-converting devices. However, issues such as rapid luminescence degradation under UV radiation and low photostability hinder their widespread use. Research suggests that the use of anisometric analogues of these complexes can address these challenges by offering high photostability and potential for applications like reusable luminescent sensors and light converters. Additionally, the development of tetrakis β-diketonate complexes with enhanced thermal stability and high quantum efficiencies provides a promising solution to the photostability problem, making them potential candidates for solid-state lighting applications. Furthermore, the study of UV laser-induced photophysical processes in europium beta-diketonate complexes revealed insights into designing advanced photonic materials with excellent photostability.Sources of β-Cyclodextrin ?

β-Cyclodextrin (β-CD) can be sourced from various materials. One study demonstrated the production of β-CD using jackfruit seed bran (JSB) as an alternative starch substrate, showing promising results for β-CD production. Additionally, β-CD has been explored as a green catalyst for synthesizing bioactive heterocyclic moieties from easily available precursors, highlighting its versatility and eco-friendly nature. Furthermore, β-CD-based polymers and nanosystems have been extensively studied for water purification applications, showcasing their effectiveness in removing impurities from wastewater through host-guest interactions and modification reactions. Moreover, β-CD has been utilized in the synthesis of nanocomposite derivatives with various nanoparticles, enhancing their biocompatibility and molecular recognition properties, thus expanding their potential applications in chemistry and biology.Should there be AI specialist in every company area to drive the machine learning integration forward ?

Having AI specialists in every company area can significantly drive machine learning integration forward. Domain specialists, who understand the data and its impact, are crucial users of ML tools, emphasizing the importance of explainability in AI applications. Companies leveraging AI, ML, and DL technologies benefit from structured methods to develop, deploy, and evolve models effectively. The growth in AI is transforming economic production structures, highlighting the need for AI specialization to guide future competitive advantages. Integrating AI specialists across various company functions can optimize model design, roles, and functions, leading to better results than traditional approaches. Therefore, having AI specialists in different areas can enhance the successful application of AI tools and drive innovation within companies.Why are iPSCs not in human clinical trials?

iPSCs are not currently in human clinical trials due to concerns regarding their immune response. Research has shown that iPSC-derived cells can be recognized and targeted by NK-cells, leading to cytotoxicity. This sensitivity to NK-cell activation, regardless of HLA-I status, highlights a potential risk in using iPSC-based therapies without considering the balance of ligands for NK-cell receptors. Additionally, the lack of inhibitory signals in iPSC-derivatives compared to parental cells may be due to their insufficient maturity, further emphasizing the need for caution in iPSC-based treatments. These immune responses and potential risks need to be thoroughly understood and addressed before iPSCs can advance to human clinical trials.Fluorescein isothiocyanate (FITC) and lissamine rhodamine (RB 200) why use one over the other?

Fluorescein isothiocyanate (FITC) and lissamine rhodamine (RB 200) are both fluorescent dyes commonly used in biological research. FITC is advantageous for visualizing specific biological molecules through fluorescence microscopy, aiding in drug delivery studies and enhancing cell uptake in a generation-dependent manner. On the other hand, lissamine rhodamine is useful for assessing the integrity of the blood-brain barrier by determining BBB permeability and extravasation from brain microvessels. FITC-labeled chitosan-based nanocarriers are extensively used in drug delivery systems, allowing for intra and extracellular tracking of the cargo. Therefore, the choice between FITC and lissamine rhodamine depends on the specific research needs, with FITC being more suitable for drug delivery and cell uptake studies, while lissamine rhodamine is preferred for assessing BBB integrity and permeability.Is 2,5-Thiophenedimethanol a Pharmacophore ?

2,5-Thiophenedimethanol can be considered a pharmacophore due to its potential in medicinal chemistry. Thiophene compounds, including 2,5-Thiophenedimethanol, are significant in drug discovery, possessing diverse biological activities and pharmacological properties. The synthesis of 2,5-disubstituted thiophene compounds, like 2,5-Thiophenedimethanol, is well-established, offering high yields and convenience in preparation. These compounds serve as intermediates in the production of various pharmaceuticals, making them valuable in medicinal chemistry research. The structural features of 2,5-Thiophenedimethanol contribute to its potential as a pharmacophore, enabling its use in the development of novel drugs with specific biological activities.From photochemistry point of view, what’s the difference between Pt(II) and Pt(IV)?

From a photochemistry perspective, the key difference between Pt(II) and Pt(IV) lies in their photoactivatable properties. Pt(IV) prodrugs, such as [Pt(OCOCH3)3(4'-phenyl-2,2':6',2''-terpyridine)][CF3SO3], are designed to be reduced to their active Pt(II) form upon light irradiation at the target site, offering spatial and temporal control. These Pt(IV) complexes can be activated by flavin-mediated photoreduction with visible light, showing faster reactivity compared to UV irradiation. Additionally, Pt(IV) derivatives like 1·TARF and 2·TARF can be selectively triggered to release toxic Pt(II) species through redox activation, enhancing their anticancer activity. Overall, Pt(IV) compounds offer a promising strategy for controlled activation and targeted delivery of platinum-based anticancer agents through photochemical means.What are the current protocols used for deriving pancreatic progenitor cells from stem cells for modeling diabetes?

Current protocols for deriving pancreatic progenitor cells from stem cells for modeling diabetes involve utilizing kits and specific culture techniques. One approach involves generating pancreatic progenitors from human pluripotent stem cells (hPSCs) using a commercially available kit, followed by differentiation into endocrine cells. Notch inhibition during aggregation of pancreatic progenitor cells has been shown to enhance endocrine cell induction in vitro and improve graft function post-implantation. Additionally, comparing differentiation protocols, it was found that a specific protocol (protocol-2) led to higher efficiency in generating early pancreatic progenitors from hESCs in a static suspension culture, making it a cost-effective option for mass production. These protocols offer valuable tools for studying diabetes and developing potential treatments through stem cell-based models.How to extract primary amin from plant?

To extract primary amines from plants, various methods can be employed based on different contexts. One method involves using a plant extract extraction device that efficiently separates plant extracts without impurities. Another approach focuses on recovering high-concentration and high-purity amines from amine-containing waste water, which is generated from power plants, through processes like cation exchange resin capture, separation, and distillation. Additionally, a method for extracting primary amines from polyether amine 200 utilizes reduced-pressure distillation and column chromatography to obtain primary amine fractions with high content and yield. These methods showcase diverse techniques for extracting primary amines from plants, emphasizing efficiency, purity, and high yields.