M
Maria João Matos
Researcher at University of Porto
Publications - 175
Citations - 4315
Maria João Matos is an academic researcher from University of Porto. The author has contributed to research in topics: Medicine & Docking (molecular). The author has an hindex of 32, co-authored 157 publications receiving 3384 citations. Previous affiliations of Maria João Matos include University of Santiago, Chile & University of Santiago de Compostela.
Papers
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Journal ArticleDOI
Chromone: A Valid Scaffold in Medicinal Chemistry
Alexandra Gaspar,Alexandra Gaspar,Maria João Matos,Maria João Matos,Jorge Garrido,Jorge Garrido,Eugenio Uriarte,Fernanda Borges +7 more
TL;DR: This work was supported by the Foundation for Science and Technology (FCT), Portugal (projects PTDC/QUI-QUI/113687/2009 and PEst-C/QUI/UI0081/2013) and SFRH/BD/61262/2009.
Journal ArticleDOI
Chemo- and Regioselective Lysine Modification on Native Proteins.
Maria João Matos,Bruno L. Oliveira,Nuria Martinez-Saez,Ana Guerreiro,Pedro M. S. D. Cal,Jean B. Bertoldo,M. Maneiro,Elizabeth R. Perkins,Julie Howard,Michael J. Deery,Justin M. Chalker,Francisco Corzana,Gonzalo Jiménez-Osés,Gonçalo J. L. Bernardes,Gonçalo J. L. Bernardes +14 more
TL;DR: It is shown that a protein–antibody conjugate bearing a site-specifically installed fluorophore at lysine could be used for selective imaging of apoptotic cells and detection of Her2+ cells, respectively and may be generally used for accessing diverse, well-defined protein conjugates for basic biology and therapeutic studies.
Journal ArticleDOI
Synthesis and study of a series of 3-arylcoumarins as potent and selective monoamine oxidase B inhibitors.
Maria João Matos,Carmen Terán,Yunierkis Pérez-Castillo,Eugenio Uriarte,Lourdes Santana,Dolores Viña +5 more
TL;DR: Coumarin 7 is the most active compound of this 6-substituted-3-arylcoumarins, being 64 times more active than selegiline and also showing the highest hMAO-B specificity.
Book ChapterDOI
Antioxidant and Pro-Oxidant Effects of Polyphenolic Compounds and Structure-Activity Relationship Evidence
TL;DR: The research and characterization of new bioactive substances, for the new design of functional foods, nutraceuticals, or drugs, has been intensified and some proofs that they act as pro-oxidant activity intimately depends on their concentration.
Book ChapterDOI
Coumarins — An Important Class of Phytochemicals
Maria João Matos,Lourdes Santana,Eugenio Uriarte,Orlando A. Abreu,Enrique Molina,Estela Guardado Yordi +5 more
TL;DR: There may be as many as 4,000 different phytochemicals having potential activity against several diseases such as cancer and metabolic or degenerative diseases, but not all are established as essential nutrients.