What is the chiral?
Best insight from top research papers
Chirality is a fundamental property of molecules that refers to their asymmetric configurational property, where an object cannot be superimposed onto its mirror image by any kind of translation or rotation. It is a universal phenomenon found in molecular and biological systems, from neutrinos to spiral galaxies . Chirality plays a crucial role in various fields such as living processes, transfer of biological information, and the activity of exogenous compounds like drugs and flavors . Chirality is prevalent in pharmaceuticals, food, bio-pharmaceuticals, and cosmetics, and it affects drug binding, antibody binding, and the authenticity of distinct flavors . Chiral molecules are the building blocks of living species, and enantiomers can have different effects on living beings, making the study of chirality important . Chirality also has implications in atomic and molecular physics, fundamental forces, and the early evolution of life .
Answers from top 5 papers
More filters
| Papers (5) | Insight |
|---|---|
30 Citations | Chirality is a phenomenon that permeates the natural world and has implications in atomic and molecular physics, as well as in the early evolution of life and biomolecular homochirality. The paper discusses the role of chirality in molecular collision dynamics. |
| Chiral refers to molecules that are not superimposable on their mirror image. They have a lack of improper rotations and are important in biological chemistry. | |
| Chirality is an asymmetric configurational property where an object cannot be superimposed onto its mirror image by any kind of translation or rotation. | |
| Chirality is a fundamental dimension of molecular structures and plays a central role in various biological and chemical processes, as mentioned in the abstract of the paper. | |
1 Citations | Chirality is a concept that is present in various industries such as pharmaceuticals, bio-pharmaceuticals, food, and cosmetics. It refers to the property of molecules that are non-superimposable on their mirror images. |
Related Questions
Isotope effect in chirality5 answersIsotope effects play a crucial role in inducing chirality in molecules. Various studies have demonstrated that isotopic substitutions can transform achiral molecules into chiral forms, affecting their enantiomeric excess. For instance, the substitution of hydrogen with deuterium or tritium in glycine can lead to changes in chirality. Additionally, isotopically chiral compounds have been shown to influence enantioselective reactions, enhancing chiral imbalances and promoting stereoimprovement. The evolution of homochirality through attrition-enhanced deracemization has also been linked to isotopic composition, with deuterated phenyl groups favoring specific enantiomers. Furthermore, in supramolecular assemblies, deuterium has been found to drive enantiomeric excess and even induce a change in the handedness of chiral aggregates. These findings highlight the significant impact of isotopic effects on chirality in various molecular systems.
What is the chiral molecule?4 answersChiral molecules are asymmetric configurational properties where an object cannot be superimposed onto its mirror image by any kind of translation or rotation. They play a fundamental role in molecular structures and are found in various systems, from molecular and biological systems to nanoelectronics and spintronics. Chirality is important in the development of life and is observed in biological molecules such as DNA and nucleic acids. Chiral molecules have the ability to selectively interact with chiral host environments, leading to changes in pharmacodynamics and pathology. Chiral-induced spin selectivity (CISS) is a recent discovery where non-magnetic chiral molecules can generate spin polarization through their structural chirality, offering advantages in spintronics and information storage. Chiral molecules can also enhance the valley contrast in monolayer transition metal dichalcogenides, making them promising for opto-valleytronic applications.
What is CD in chirality detectoin?4 answersCircular dichroism (CD) spectroscopy is a technique used for the enantiomer-specific analysis of chiral samples. It is of great significance in academia and industry. CD spectroscopy measures the differential absorption of left- and right-circularly polarized light by chiral molecules, providing information about their structural and stereochemical properties. CD spectra alone, however, cannot determine the enantiomer composition of a chiral sample. The molar concentration of chiral molecules, which is usually measured on a different platform, needs to be normalized with the CD spectrum. CD analysis can be combined with other techniques such as UV or fluorescence measurements to determine the yield and enantiomeric ratio of chiral compounds. CD spectroscopy can also be used in gas-phase chiral discrimination, offering higher efficiency and background-free insight into chiral interactions. Additionally, CD analysis can be combined with Raman scattering to monitor molecular interactions and spectroscopic properties.
What mean is "Reactions carried out with achiral reactants can often lead to chiral products."?3 answersReactions carried out with achiral reactants can often lead to chiral products, meaning that the starting materials themselves do not possess chirality, but the resulting products do have a specific handedness. This can be achieved through various methods, such as using chiral catalysts or creating an asymmetric autocatalytic system. In one study, it was shown that an enantiopure product can be obtained from achiral starting materials through a single organic reaction, where the chiral product precipitates from the solution, leading to chiral amplification and the formation of an enantiopure end state. Another approach involved the use of a single isomer of a simple chiral compound as a cocatalyst, which resulted in the synthesis of two enantiomers of a chiral polymer from achiral monomers. Additionally, grinding achiral reaction components with an achiral catalyst was found to induce solid-state deracemization, leading to a controlled final configuration of the product. These examples demonstrate that chiral products can be obtained from achiral reactants through various strategies.
How to calculate chirality of polarization?5 answersChirality of polarization can be calculated by analyzing the spatial polarization of electronic clouds in molecules and the spatial arrangements of atoms into chiral molecular structures. This concept connects chirality and polarization, showing that chirality, like charge, can be polarized. The polarization of chirality leads to fundamental consequences, particularly in the interaction of light with chiral matter. By creating chirality-polarized optical fields of alternating handedness, it is possible to control and quantify the enantio-sensitive response of chiral molecules. Additionally, unidirectional emission of light can be achieved using elliptical dipoles, which increases the area suitable for chiral interactions and improves coupling efficiencies. Chirality-locked valley polarization has also been demonstrated in photonic graphene, where a chiral source selectively excites one preferred valley depending on its chirality. These studies provide insights into the calculation and manipulation of chirality in polarization.
What is the recent advances of chiral high-performance liquid chromatography drugs?4 answersRecent advances in chiral high-performance liquid chromatography (HPLC) for drugs have focused on improving selectivity, efficiency, and speed of enantiomeric separations. These advancements have been beneficial for various scientific disciplines, including high-throughput research. Some of the key developments include the use of new particle morphologies, bonding chemistry of chiral selectors, and high-efficiency packing procedures. Special detectors have also been developed for enantiomeric separations. Additionally, chiral screening techniques and new high-efficiency chiral separation methods and stationary phases have been introduced. These include the use of achiral UHPLC columns, chiral additives in the run buffer, UHPLC chiral stationary phases, and superficially porous particle-based chiral stationary phases. Instrumental considerations for achieving ultrafast enantiomeric separations have also been discussed. Overall, these advancements in chiral HPLC have led to improved separation and detection methods for chiral drugs, providing valuable insights for further development of analytical methods.