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What is the effect of ML385 on A549 cells?

Protein kinase B

PI3K/AKT/mTOR pathway

Chrysanthemum indicum

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ML385, a small molecule NRF2 inhibitor, has not been previously investigated in lung squamous cell carcinoma (LUSC). On the other hand, various compounds have shown effects on A549 lung cancer cells. Chrysanthemum indicum flavonoids have been found to inhibit proliferation and induce apoptosis in A549 cells in a concentration- and time-dependent manner. Cantharidin, derived from blister beetles, inhibits migration and invasion of A549 cells by attenuating matrix metalloproteinase 2 activity through the PI3K/Akt pathway. Additionally, aminoethyl-chitooligosaccharide (AE-COS) has demonstrated the ability to reduce A549 cell proliferation, suppress COX-2 expression, and induce apoptosis, making it a potential chemotherapy agent for lung cancer treatment.

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Journal Article•DOI Anti-metastatic effect of cantharidin in A549 human lung cancer cells Youngmin Kim, Min Jeong Ku, Young-Jin Son, Jung-Mi Yun, Seong-Hwan Kim, Sang Yeol Lee - Show less +5 more 23 Feb 2013-Archives of Pharmacal Research 35 Citations	Not addressed in the paper.
Open access•Posted Content•DOI Phospho-Proteomic Analysis of The Effect of Merecidin Inhibiting the Human Lung Adenocarcinoma A549 Cells xiuqing wang, Qinqin Jia, Qiannan Zhang, Tingting Yang, Jinxuan Song, Yarong Wang - Show less +5 more 03 Apr 2021	Not addressed in the paper.
Journal Article•DOI The NRF2 antagonist ML385 inhibits PI3K‐mTOR signaling and growth of lung squamous cell carcinoma cells Lili Ji, Nadeem Moghal, Xinru Zou, Yixuan Fang, Shuning Hu, Yuhui Wang, Ming-Sound Tsao - Show less +6 more 28 Oct 2022-Cancer Medicine 5 Citations	ML385, an NRF2 antagonist, inhibits PI3K‐mTOR signaling and growth of lung squamous cell carcinoma cells, including A549 cells, suggesting potential therapeutic benefits in lung squamous cell carcinoma.
Open access Research on the Effect of A549 Lung Cancer Cells Treated by Chrysanthemum Indicum Flavonoids LI Yuehu 01 Jan 2014 1 Citations	Not addressed in the paper.
Open access•Journal Article•DOI Antiproliferative Effect of Aminoethyl-Chitooligosaccharide on Human Lung A549 Cancer Cells. Dai-Hung Ngo, Dai-Nghiep Ngo, Se-Kwon Kim, Thanh-Sang Vo - Show less +3 more 18 May 2019 12 Citations	Not addressed in the paper.

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