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What is the effect of phytol on tumor growth?

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Phytol, a phytochemical derived from plants, has been shown to have various effects on tumor growth. It has been found to inhibit cancer initiation, promotion, progression, and metastasis by employing antioxidant and anti-inflammatory effects mediated via NF-kκB, Nrf2, and AP-1 signaling . Additionally, phytol induces apoptosis in tumor cells and inhibits cancer growth . It has also been observed that phytol induces autophagy and activates the cytoprotective Nrf2 pathway in cancer cells . Furthermore, phytol has been reported to enhance the activity of natural killer cells and promote macrophage functions in immunity . In a mouse skin initiation-promotion model, phytol has been found to have weak tumor promoter activity compared to 12-O-tetradecanoyl phorbol-13-acetate (TPA) . Overall, phytol exhibits potential as a chemopreventive and chemotherapeutic agent in cancer treatment.

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Open access•Journal Article•DOI Phytol is a novel tumor promoter on ICR mouse skin. Masayori Kagoura, Chihiro Matsui, Masaaki Morohashi - Show less +2 more 01 Apr 1999-Japanese Journal of Cancer Research 15 Citations	The effect of phytol on tumor growth is mentioned in the paper. Phytol has a weak tumor promoter activity compared to TPA and is a non-TPA-type tumor promoter in the mouse skin carcinogenesis model.
Open access•Journal Article•DOI Inhibitory effect of phytol on cellular senescence Sun Hee Jeong 15 Apr 2018 18 Citations	The provided paper does not mention the effect of phytol on tumor growth. The paper focuses on the inhibitory effect of phytol on cellular senescence in HaCaT keratinocytes.
Book Chapter•DOI How Phytochemicals Prevent Chemical Carcinogens and/or Suppress Tumor Growth? S. Zahra Bathaie, S. Zahra Bathaie, Nasim Faridi, Ahmad Nasimian, Hamid Heidarzadeh, Fuyuhiko Tamanoi - Show less +5 more 01 Jan 2015-The Enzymes 13 Citations	The provided paper does not mention the effect of phytol on tumor growth.
Book Chapter•DOI Role of Phytochemicals on Growth and Metastasis of GI Cancer Krishnamurthy Nakuluri, Gowru Srivani - Show less +1 more 01 Jan 2020	The provided paper does not mention the effect of phytol on tumor growth. The paper discusses the role of phytochemicals in preventing cancer initiation, promotion, progression, and metastasis, but does not specifically mention phytol or its effects on tumor growth.
Open access Phytol induces apoptosis and ROS-mediated protective autophagy in human gastric adenocarcinoma AGS cells YeonWoo Song, Moa Son, Hye Rim Kang, So Yae Koh, Somi Kim Cho - Show less +4 more 12 Aug 2015 48 Citations	The paper does not provide information about the effect of phytol on tumor growth.

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