scispace - formally typeset
Search or ask a question

What is the recent research on kidney tumours? 


Best insight from top research papers

Recent research on kidney tumors has focused on various aspects of these malignancies. Studies have explored the role of microRNAs (miRNAs) in renal cell carcinoma (RCC), with more than 82 miRNAs identified as being involved in renal cancers . The use of exosomes as mediators of intercellular communication in the tumor microenvironment has also been investigated, with potential applications for the diagnosis and treatment of kidney cancer . Additionally, a retrospective analysis of patients who underwent surgical removal of clear cell carcinoma found morpho-functional changes in the kidneys depending on tumor size and the presence of systemic diseases . The incidence of new cases of renal cell carcinoma has been increasing, and the role of trans-arterial embolization (TAE) in the treatment of these tumors has been explored, although the evidence for its effectiveness is inconclusive . Furthermore, the new WHO classification of renal tumors has improved the understanding and accurate diagnosis of these neoplasms .

Answers from top 5 papers

More filters
Papers (5)Insight
The recent research on kidney tumors discussed in the paper focuses on the histomorphological features of various renal tumors and the classification of these tumors based on the new WHO classification.
The recent research on kidney tumors discussed in the paper focuses on the use of trans-arterial embolization (TAE) in both neoadjuvant and palliative treatment regimens. The paper highlights the effects of TAE on reducing blood loss, surgery duration, and tumor volume, as well as its potential to increase cancer-specific survival rates after radical intervention. However, the paper also mentions conflicting findings regarding the ability of TAE to improve overall survival and its effectiveness in certain cases such as inferior vena cava thrombosis. The paper suggests the need for further randomized studies to establish the indications and effects of TAE in patients with kidney tumors.
The recent research analyzed the examination and treatment results of 30 patients who underwent surgical removal of clear cell carcinoma in the kidneys. It studied the effect of tumor size and the presence of systemic diseases on morpho-functional changes in the kidneys.
The recent research on kidney tumors focuses on the role of microRNAs (miRNAs) in renal cancer, including their involvement in progression, diagnosis, therapy targeting, and prognosis of renal cell carcinoma (RCC).
The provided paper discusses the role of exosomes in the diagnosis and treatment of kidney cancer, but it does not provide specific information on recent research on kidney tumors.

Related Questions

What is a survival rate of Kidney cancer?4 answersThe survival rate of kidney cancer varies depending on the region and stage of diagnosis. In Asian countries, the one-year survival rate is 71%, the five-year survival rate is 69.4%, and the 10-year survival rate is 62.3%. In England, the survival outcomes for kidney cancer remained relatively unchanged, with age-standardized mortality rates remaining stable over the study duration. In the United States, the overall 5-year survival rate for kidney cancer is 76%, with regional disease having a 66.7% survival rate and metastatic disease having an 11.7% survival rate. Additionally, specific genetic mutations have been associated with reduced survival in clear cell renal cell carcinoma, such as VHL, BAP1, SDHA, SDHD, and ARID1A.
What are the latest studies looking at epigenetics and cancer?5 answersRecent studies have focused on the role of epigenetic modifications in cancer progression and treatment. Epigenetic changes, such as histone modification, DNA methylation, and non-coding RNA, have been shown to play a critical role in the development of therapeutic resistance in cancer. Targeting these epigenetic modifications with specific drugs, such as DNA methyltransferase inhibitors and histone deacetylase inhibitors, has the potential to reverse drug resistance and restore sensitivity to standard therapies. Additionally, the interplay between epigenetics and cancer immunology has been explored, with the aim of developing therapeutics that combine both approaches. The concept of the epigenetic landscape, which describes potential cellular fates and regulatory processes, has been applied to understand cancer etiology and the plasticity of cancerous states. Advances in single-cell analysis and molecular assays have enriched our understanding of the diversity of phenotypic states defined by epigenetic control. Overall, these studies contribute to our understanding of how epigenetic modifications influence cancer progression and provide insights for the development of targeted therapies.
What is the current state of the art in CAR-T cell therapy for kidney cancer?4 answersCAR-T cell therapy is an emerging treatment modality for kidney cancer that shows promise in improving patient outcomes. The approval of nivolumab as a second-line monotherapy and the recent approval of novel combination therapies as first-line treatment have established the significance of immunotherapy in renal cell carcinoma (RCC). CAR-T cell therapy involves genetically engineering T cells to express chimeric antigen receptors (CARs) that target specific tumor antigens. While CAR-T cell therapy has shown promise in hematological malignancies, its application in solid tumors, including RCC, is still being investigated. Challenges in CAR-T cell therapy for RCC include the lack of specific molecular targets, depletion of CAR-T cells, a hostile tumor microenvironment, and on/off-tumor toxicities. Ongoing research aims to overcome these obstacles and improve the efficacy of CAR-T cell therapy for kidney cancer.
How can new diagnostic methods be developed to improve the early detection and diagnosis of kidney cancer?5 answersNew diagnostic methods can be developed to improve the early detection and diagnosis of kidney cancer through the integration of multi-modal ultrasound videos. This can be achieved by using a novel multi-modal ultrasound video fusion network that effectively performs multi-modal feature fusion and video classification for renal tumor diagnosis. Additionally, the use of deep learning models such as Convolutional Neural Networks (CNNs) and Artificial Neural Networks (ANNs) can aid in the early diagnosis of kidney cancer by detecting kidney images and analyzing blood samples dataset values. Furthermore, the development of a hybrid neural fuzzy inference system combining CNNs with machine learning techniques has shown promise in accurately detecting and segmenting kidney tumors. The use of artificial intelligence (AI) and radiomics has also allowed for the development of AI-based computer-aided diagnostic/prediction (CAD/CAP) systems, which can aid in the early diagnosis of kidney cancer and prediction of clinical outcomes.
What is the latest research on cancer therapy?5 answersRecent research on cancer therapy has focused on various approaches including cell membrane-camouflaged nanoparticles for targeted drug delivery and therapy. Another strategy involves the use of antibody-drug conjugates (ADCs) to selectively deliver potent cytotoxic agents to tumor cells, improving efficacy and reducing systemic adverse events. Advances have also been made in the development of safe and efficient cancer nanomedicines, such as stem cell therapy, targeted therapy, ablation therapy, nanoparticles, natural antioxidants, radionics, chemodynamic therapy, sonodynamic therapy, and ferroptosis-based therapy. Additionally, there has been a growing interest in cancer gene therapy, with a focus on materials science and nanotechnology, gene delivery, and drug delivery. Furthermore, non-protein target drugs, particularly RNA therapeutics, including oligonucleotide drugs and mRNA vaccines, have shown promise in cancer treatment. These advancements highlight the importance of targeted drug delivery, personalized therapies, and innovative treatment modalities in the field of cancer therapy.
What current research in carcinogenesis is available?5 answersCurrent research in carcinogenesis includes studies on the molecular and genetic alterations leading to hepatocellular carcinoma (HCC). Enzymes such as epoxide hydrolases are being investigated for their role in detoxification of carcinogenic compounds as well as signal transduction and inflammatory control. Field cancerization and molecularly targeted prevention are being explored in the context of oral cancer development. The molecular basis of carcinogenesis, including the role of various genes, is being studied with a focus on chemical carcinogenesis. Different models of carcinogenesis, such as the virus model, somatic mutation model, and reading-error model, are being reviewed, along with the electronic theory of cancer. These studies aim to improve our understanding of the mechanisms underlying cancer development and to identify potential targets for prevention and treatment.

See what other people are reading

How aml is treated?
5 answers
AML is treated through various approaches. Traditional cytotoxic regimens are initially employed, followed by targeted therapies like FLT3 inhibitors and IDH inhibitors, which have shown efficacy in specific patient populations. Achieving complete remission (CR) is crucial, with consolidation treatment options including chemotherapy or allogeneic hematopoietic cell transplant (HCT) to improve long-term survival. Novel therapies under investigation for AML include antibody therapies targeting CD47 and TIM-3, bispecific antibodies, and CAR-T-cell therapies, aiming to enhance treatment outcomes. Personalized treatment based on genomic signatures is gaining importance, with a focus on targeting specific pathways involved in AML cell survival, drug resistance, and immune evasion to improve overall treatment responses. Further exploration of combination therapies targeting multiple pathways is warranted for broader patient benefit.
What are the implications of BRCA1 mutation on the efficacy of personalized therapeutic interventions for breast cancer?
5 answers
BRCA1 mutations play a significant role in the efficacy of personalized therapeutic interventions for breast cancer. Mutations in BRCA1 lead to DNA repair defects, making tumors more vulnerable to therapies like Poly (ADP-ribose) polymerase inhibitors (PARPi). These mutations result in homologous recombination repair deficiencies, affecting responses to platinum salt therapies and PARP inhibitors. However, the efficacy of these treatments can be impacted by the development of resistance due to interconnected DNA repair pathways compensating for each other. Additionally, BRCA1 promoter methylation can lead to poor outcomes and adaptive chemoresistance, altering therapeutic responses in TNBC and ovarian cancers. Understanding the implications of BRCA1 mutations is crucial for tailoring effective treatment strategies in breast cancer patients.
What are the potential mechanisms underlying the association between ICIP and TMB, and how might these influence treatment decisions?
5 answers
The association between immune checkpoint inhibitor therapy (ICI) and tumor mutational burden (TMB) involves several key mechanisms. High TMB has been linked to improved survival with ICI treatment, but not all high-TMB patients respond well. Specific gene alterations impact outcomes differently in TMB-high and TMB-low patients, influencing response to ICI. For instance, mutations in genes like STK11 and E2F3 are associated with worse outcomes in TMB-high tumors, while mutations in genes like NTRK and PTPRD are linked to better outcomes. Additionally, the immune-excluded phenotype, characterized by high stromal TIL and low intratumoral TIL density, is correlated with high TGFBs and poor response to immunotherapy. These insights can guide treatment decisions by helping identify patients likely to benefit from ICI based on their TMB status and specific gene alterations.
What is the safest treatment for pedunculated fibroids?
5 answers
The safest treatment for pedunculated fibroids includes various options with favorable outcomes. Magnetic resonance-guided focused ultrasound (MRgFUS) ablation has been shown to be safe for treating pedunculated subserosal uterine leiomyomas, with no evidence of complications related specifically to these fibroids. Uterine artery embolization has also been successful in treating pedunculated subserosal fibroids, resulting in symptom resolution and significant reductions in fibroid size. Additionally, a new method involving vaginal removal of submucous fibroids has shown high success rates, avoiding hysterectomy and abdominal myomectomy in most cases, with minimal morbidity and successful pregnancies post-procedure. These findings collectively suggest that MRgFUS, uterine artery embolization, and vaginal removal techniques are safe and effective options for treating pedunculated fibroids.
Cancer and target therapy
5 answers
Targeted therapy for cancer is a personalized approach that aims to specifically target cancer cells while minimizing damage to healthy cells by focusing on molecular or genetic changes unique to cancer cells. This method has shifted oncology towards individualized treatment based on deep molecular analysis, allowing for tailored therapies guided by the tumor's specific molecular alterations. While traditional treatments like surgery and chemotherapy have limitations such as adverse effects and metastasis, targeted therapy offers a promising alternative by blocking the growth and spread of cancer cells through specific molecule targeting. The foundation of precision medicine, targeted therapy targets proteins controlling cancer cell growth, with advancements like stimuli-responsive drug delivery systems enhancing treatment efficacy. Despite challenges like drug resistance, targeted therapy presents significant therapeutic advantages and development prospects in cancer treatment.
Cancer cell membrane borospherene for targeted delivery
5 answers
Cancer cell membrane-coated boron nitride nanomaterials have shown great potential for targeted drug delivery in cancer therapy. These biomimetic nanoplatforms combine the advantages of boron nitride nanoparticles (BN) with the targeting ability of cancer cell membranes (CCM). By encapsulating BNs with cancer cell membranes, these nanoplatforms exhibit enhanced dispersibility, cytocompatibility, and homologous targeting of cancer cells, leading to increased cellular uptake and improved cytotoxicity against cancer cells. Furthermore, the incorporation of cancer cell membrane onto BN nanospheres has shown to enhance tumor-selective drug delivery, resulting in efficient tumor inhibition. This innovative approach holds promise for personalized and targeted cancer therapy, offering a potential solution to the challenges of drug delivery in cancer treatment.
What are the historical milestones in the understanding and treatment of skin cancer?
5 answers
The historical milestones in the understanding and treatment of skin cancer have evolved significantly over time. From the early observations of skin cancer as the most frequently occurring neoplastic disease in light-skinned populations, to the development of targeted therapies like Photodynamic Therapy (PDT) that selectively destroy tumor cells without harming normal tissues. Additionally, the progress in basic science, clinical medicine, and pharmacology has led to a better comprehension of skin cancer dynamics. Noteworthy contributions include the introduction of PDT as a non-invasive cancer therapy using photosensitizers, light, and oxygen for targeted treatment. These milestones highlight the continuous efforts to enhance prevention, diagnosis, and treatment strategies for various types of skin cancer, emphasizing the importance of comprehensive education, reliable diagnosis, and diligent aftercare.
How can i measure protease activity of lung?
5 answers
To measure protease activity in the lung, innovative methods utilizing nanosensors and machine learning have been developed. These methods involve detecting protease enzyme activity in lung cancer patients through blood samples. By assembling biosensors on a graphene backbone with fluorescently tagged peptides, altered protease activation indicative of cancer can be identified. These biosensors have shown high sensitivity and specificity in detecting early-stage lung cancer, providing a cost-effective tool for diagnosis. Additionally, multiplexed nanosensors have been engineered to quantify protease activity in vivo, allowing for the dynamic monitoring of enzyme activity levels over time in response to targeted therapy. This integrated approach enables the comprehensive characterization of protease dysregulation in lung cancer at various levels, from organism to cellular phenotype.
What are the recent advancement in the molecular imaging method used in HCC?
5 answers
Recent advancements in molecular imaging methods for assessing changes in the hepatocellular carcinoma (HCC) microenvironment post locoregional treatment have shown promise. These advancements are crucial due to the complexity of HCC and its microenvironment, impacting treatment efficacy. Imaging techniques are evolving towards a quantitative paradigm, integrating radiomics and quantitative imaging for a more comprehensive evaluation of the liver and its function. Additionally, nanotechnologies have emerged as a valuable tool in HCC management, offering targeted and traceable therapeutic strategies that can enhance treatment efficacy and predict tumor responses. Furthermore, advanced imaging techniques such as contrast-enhanced ultrasound, CT perfusion, Dynamic Contrast-enhanced MRI, diffusion-weighted imaging, and radiomics have improved the diagnostic accuracy and characterization of HCC. These collective advancements in molecular imaging are crucial for optimizing treatment protocols and improving patient outcomes in HCC management.
Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies
5 answers
Cancer stem cells (CSCs) play a crucial role in tumor initiation, progression, and therapy resistance. These cells exhibit high plasticity and resistance to standard therapies, making them challenging targets for treatment. Biomarkers like CD133, CD44, ABCG2, and ALDH have been identified for certain CSCs, aiding in their characterization. The signaling pathways involved in CSC development, such as Wnt, Notch, and Hedgehog pathways, are potential targets for novel anticancer strategies. Despite debates on their existence, targeting CSCs holds promise for personalized therapies, aiming to overcome their intrinsic resistance and reduce the risk of relapse and metastasis. Identifying and monitoring residual CSCs and senescent tumor cells post-therapy using specific biomarkers is crucial for effective follow-up and treatment. A future perspective involves immune-mediated strategies like chimeric antigen receptor-based approaches for eliminating chemotherapy-resistant cells and CSCs in personalized therapeutic approaches.
How do these techniques compare in terms of efficiency and cost-effectiveness?
4 answers
Hand-assisted, standard, and robot-assisted laparoscopies for nephrectomy are cost-effective compared to open surgery, with hand-assisted laparoscopy being the most cost-effective option, despite robot-assisted laparoscopy offering the best clinical outcomes but at a higher cost. In the realm of whole breast radiotherapy, field-in-field (FIF) technique emerges as the most cost-effective option, followed by hybrid intensity modulated radiotherapy (IMRT) and multiple arc VMAT, with FIF having the lowest ICER value. Moreover, the use of standard metal crowns for primary molars restoration is proven to be more clinically successful and cost-effective in the long term compared to other restoration techniques. Additionally, viscoelastometric tests like ROTEM delta are more cost-effective than standard laboratory tests, showcasing their superiority from a healthcare provider's perspective.