Search or ask a question

What is the recommended infusion of lr for pancreatitis?

Context (archaeology)

Infusion therapy

Pancreatic cancer

Best insight from top research papers

The recommended infusion of Lactated Ringer's (LR) solution for pancreatitis varies based on different studies. One study suggests that aggressive intravenous fluid hydration with 3500 mL of LR over 9 hours reduces post-ERCP pancreatitis incidence . However, another study found that continuous infusion of high-volume LR over 24 hours did not significantly impact post-ERCP pancreatitis incidence or severity . Additionally, there is evidence to support the superiority of Ringer lactate solution over normal saline solutions in fluid resuscitation for acute pancreatitis . Therefore, while there are varying approaches to fluid infusion in pancreatitis, it is essential to consider individual patient factors and closely monitor fluid balance and response to treatment.

Answers from top 4 papers

PDF

Open Access

More filters

Papers (4)	Insight
Journal Article•DOI Continuous Regional Arterial Infusion Therapy for Acute Necrotizing Pancreatitis Due to Mycoplasma pneumoniae Infection in a Child Motoo Nakagawa, Hiroyuki Ogino, Masashi Shimohira, Masaki Hara, Yuta Shibamoto - Show less +4 more 15 May 2009-CardioVascular and Interventional Radiology 8 Citations	Continuous regional arterial infusion therapy with gabexate mesilate and meropenem trihydrate is recommended for pancreatitis, as shown to be safe and effective in treating necrotizing pancreatitis in children.
Journal Article•DOI Continuous Infusion of Fluid Hydration Over 24 Hours Does Not Prevent Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis Arunchai Chang, Arunchai Chang, Nonthalee Pausawasdi, Nonthalee Pausawasdi, Phunchai Charatcharoenwitthaya, Uayporn Kaosombatwattana, Tassanee Sriprayoon, Julajak Limsrivilai, Varayu Prachayakul, Somchai Leelakusolvong - Show less +9 more 15 Oct 2021-Digestive Diseases and Sciences 1 Citations	Continuous infusion of 3600 mL of lactated Ringer's solution over 24 hours did not prevent post-ERCP pancreatitis, indicating this volume may not be sufficient for optimal hydration in pancreatitis prevention.
Open access•Journal Article•DOI Update on the strategy for intravenous fluid treatment in acute pancreatitis T Yaowmaneerat, Apichet Sirinawasatien - Show less +1 more 05 May 2023-World Journal of Gastrointestinal Pharmacology and Therapeutics	LR (Ringer lactate solution) is recommended over normal saline for fluid resuscitation in acute pancreatitis. Optimal infusion rate and amount should be moderate to avoid adverse events and mortality.
Book Chapter•DOI Arterial infusion and arterial chemoembolization for pancreatic cancer Zhi Guo, Haipeng Yu - Show less +1 more 01 Jan 2021 1 Citations	Not addressed in the paper.

My columns

Related Questions

What recommendations shoule be followed to treat a type 2 diabetes in a patient transplantes from pancreas?5 answersFor treating type 2 diabetes in a patient transplanted from the pancreas, it is crucial to consider the patient's specific condition and history. Pancreas transplantation, especially in type 2 diabetes patients, can lead to favorable patient and graft survival outcomes, emphasizing the need to identify those who would benefit most from this procedure. The choice of therapy should focus on maintaining good glycemic control without hypoglycemia, potentially utilizing sodium-glucose cotransporter-2 inhibitors (SGLT-2i) to take advantage of renal protection and reduced cardiovascular risk. Additionally, it is essential to carefully monitor the patient's renal function and adjust medications accordingly to improve outcomes and prevent complications. Ultimately, individualized treatment plans, considering the patient's unique characteristics and response to therapy, are vital for managing type 2 diabetes post-pancreas transplantation effectively.

What rate does the Waterfall trial suggest for acute pancreatitis?4 answersThe WATERFALL trial suggests a moderate aggressive rate for fluid resuscitation in acute pancreatitis. The trial compared aggressive fluid resuscitation with lactated Ringer's solution (LR) to moderate fluid resuscitation. Aggressive resuscitation involved a bolus of LR at a dose of 20 mL/kg of body weight administered over 2 hours, followed by infusion at a rate of 3 mL/kg per hour. Moderate fluid resuscitation was defined as LR at a dose of 1.5 mL/kg per hour, with the option of a 10 mL/kg bolus if the patient had hypovolemia. The trial found no statistical clinical benefit in patients treated with aggressive fluid resuscitation compared to moderate resuscitation. In fact, patients receiving aggressive fluid treatment had a higher incidence of fluid overload compared to the moderate resuscitation group.

Is the administration of lipid emulsion safe for the pancreatic fistula?5 answersThe administration of lipid emulsion appears to be safe for patients with pancreatic fistula, based on multiple studies proving their safety in a total of nearly 100 patients. Intralipid, a commonly used intravenous fat emulsion, is considered a safe component of intravenous nutritional support for patients with pancreatic fistulas. However, it may minimally increase the volume, bicarbonate, and amylase concentrations of the output. Rare cases of pancreatitis have been reported after the administration of intravenous fat emulsions, but it is unclear whether hypertriglyceridemia is a prerequisite for this complication. Overall, the evidence suggests that lipid emulsion administration is safe for patients with pancreatic fistula, but caution should be exercised to avoid hypertriglyceridemia.

What are the best antibiotic prophylaxis options for patients undergoing pancreatic surgery?5 answersThe optimal antibiotic prophylaxis for patients undergoing pancreatic surgery remains unclear. However, several studies suggest that broad-spectrum antibiotics may be more effective in preventing surgical site infections (SSIs) compared to standard prophylactic antibiotics. One study found that piperacillin-tazobactam was associated with a lower rate of postoperative SSIs compared to standard antibiotic therapy. Another study showed that the current standard antibiotic prophylaxis may be inadequate in covering microbes prevalent in postoperative infections after pancreatic surgery. Although cefazolin and metronidazole are commonly used, they may not be sufficient in preventing infectious complications. Therefore, targeted antibiotics that specifically address organisms prevalent in bile instrumentation or based on culture data may be more effective in reducing postoperative infections. Further research is needed to determine the best antibiotic prophylaxis options for patients undergoing pancreatic surgery.

What is the best treatment for pancreatic cancer in people with diabetes?4 answersThe best treatment for pancreatic cancer in people with diabetes is still being studied, but there are some promising options. Metformin, an antidiabetic drug, has shown potential as an adjunctive therapeutic agent for pancreatic cancer. It has demonstrated antineoplastic effects and may improve survival in pancreatic cancer patients with pre-existing diabetes mellitus. Targeting the insulin/IGF pathway is also a focus of research, as insulin resistance and hyperinsulinemia have been identified as factors related to pancreatic cancer risk. Additionally, combining anti-diabetic drugs with other anti-cancer drugs and phytochemicals may help prevent and treat pancreatic cancer. However, further studies and clinical trials are needed to provide stronger evidence-based recommendations for the treatment of pancreatic cancer in people with diabetes.

What is the concentration of pancreatic polypeptide in the fasted state (measured in nanograms per milliliter blood)?5 answersThe concentration of pancreatic polypeptide in the fasted state ranges from 0.36 to 1,648 ng/mL blood.

See what other people are reading

What are current gaps in finance PhD re?

Current gaps in finance PhD research include a focus on structured supervision styles that may hinder the inquiry spirit intrinsic to academia, as noted in Australia and New Zealand. Additionally, there is a lack of attention to the modalities of funding the clean cooking transition at a macro level, leading to a chronic shortfall of finance for early-stage clean cooking companies and poorly targeted public finance for innovation. Furthermore, there is a need for research on the influence of academic research journals on the design of finance doctoral education, as empirical studies in this area are lacking. These gaps highlight the importance of addressing supervision styles, funding mechanisms, and the influence of academic research in shaping finance PhD programs.How online learning have impacted the four domins of quality of life of secondary studnets from rural area?

Online learning has significantly impacted the quality of life of secondary students from rural areas in various ways. The studies highlight that online learning during the Covid-19 pandemic has led to challenges such as internet connectivity issues, distractions during classes, and difficulties in understanding the material. However, it has also brought about positive outcomes like enhanced active learning, technological competence, and learner autonomy among students in remote and underprivileged schools. Additionally, the digital gaps amplified by the pandemic have deepened in vulnerable areas, affecting digital literacy levels and access to technology among rural secondary students, ultimately influencing their online learning experience and overall quality of life. These findings underscore the complex impact of online learning on the quality of life of secondary students from rural areas, emphasizing the need for targeted interventions to address the challenges and leverage the benefits of online education.What is the significance of road safety in promoting sustainability?

Road safety plays a crucial role in promoting sustainability by addressing the negative impacts of road accidents on society and the economy. Road traffic fatalities are a significant global concern, with young people being particularly vulnerable. Investments in road infrastructure, especially in high-income countries, have shown to reduce mortality rates due to road accidents. Implementing science-based road safety management, such as safety performance functions and designing forgiving road infrastructure, can significantly decrease the severity of collisions and enhance overall road safety. Additionally, the application of Internet of Things (IoT) technologies in road safety, from driver state detection to car crash detection, further emphasizes the importance of road safety for sustainable cities and communities. Prioritizing safe mobility for all aligns with Sustainable Development Goals, contributing to social sustainability in transport.How free play influence children's conceptual development?

Free play significantly influences children's conceptual development by fostering the construction of large conceptual structures and intuitive theories, as children actively engage in self-directed learning and exploration. Zi Lin Sim and Fei Xu's research demonstrates that young children can learn high-order generalizations through free play, which are foundational for building larger conceptual structures, with their performance in free play comparable to didactic conditions. This active engagement in their environment is crucial for cognitive development, as highlighted by the constructivist views on cognitive development. The urban or suburban built environment plays a pivotal role in facilitating or hindering children's opportunities for outdoor free play, which in turn affects their physical, cognitive, social, and emotional development. Features such as proximity to play spaces, protection from traffic, and opportunities for social connection are essential for supporting outdoor free play. Furthermore, free play with blocks has been observed to enhance preschoolers' skills in observation, communication, experimentation, and rationale development, which are precursors to engineering behavior and align with the Design Process model in engineering. In school settings, the introduction of free play times has been shown to elicit significant improvements in children's motor, cognitive, and social performance, underscoring the value of incorporating free play into educational practices. Early childhood teachers recognize the importance of free play for development and learning, with their involvement being crucial for facilitating socially assisted learning and abstract thinking. However, the geographical and social contexts, including class differences, significantly influence children's access to and experiences of free play, affecting their ability to engage in diverse playful spaces. Digital environments offer new opportunities for free play, impacting children's development, identity formation, and sociability. However, the commercial interests in digital contexts can restrict children's agency and freedom, suggesting a need for a 'playful by design' approach to promote imaginative and open-ended play while ensuring safety and privacy. Research on children's perceptions of play and learning in preschool settings further emphasizes the importance of understanding children's views on free play and structured learning, as these insights can inform the design of educational environments that support conceptual development. Finally, the application of cultural-historical theory to examine the relations between everyday and scientific concepts within playful contexts reveals that conceptually oriented play-based programs can focus children's play on conceptual connections, facilitating the development of scientific thinking.How many social policy laws there in Bangladesh?

Bangladesh has a complex legal landscape concerning social policies. The country has established laws under the legislative and parliamentary affairs division, encompassing 956 Acts, Ordinances, and President's Orders compiled in the Bangladesh Code from 1836 to 2007. However, specific social policy laws addressing social enterprises, child protection, and child marriage are also present. For instance, there are existing policies and regulatory affairs related to social enterprise formation and operations, highlighting the need for a specific policy for social enterprises in Bangladesh. Additionally, laws such as the Children Act 1974, Children Rules 1976, and Children Act 2013 aim to protect children's rights, but despite these laws, children in Bangladesh are still exploited and ill-treated, indicating the need for legal reforms in child protection. Moreover, the Child Marriage Restraint Act 2017 addresses child marriage, allowing minors to marry under special circumstances with parental consent and court approval, reflecting the intersection of legal, cultural, and religious aspects in social policy in Bangladesh.How do real-world IoT networks ensure the mitigation of risk in RPL through theoretical solutions?

Real-world IoT networks employ a variety of theoretical solutions to ensure the mitigation of risks in RPL, focusing on enhancing security, reliability, and performance. The STACK project aims to improve IoT transmission capabilities and mitigate attacks through performance and interference monitoring, integrating solutions with an intelligent edge to address the exploitation of the RPL protocol, which poses a significant threat to IoT networks. A novel Intrusion Detection System (IDS) named AMI Attack-aware Intelligent Machine learning IDS (AIMS) utilizes a Stacked Ensemble machine learning model for predicting, detecting, and mitigating RPL security attacks in Advanced Metering Infrastructure (AMI), showcasing the application of advanced machine learning techniques for security. Further, the Security, Mobility, and Trust-based model (SMTrust) addresses routing attacks by incorporating trust factors and metrics, including mobility-based metrics, to improve topology stability, reduce packet loss rate, and increase throughput with minimal impact on power consumption. The Secure RPL (Sec-RPL) protocol introduces a multi-phase approach including node authentication, congestion control, and attack detection using lightweight algorithms and optimization techniques to enhance network reliability and performance. A lightweight algorithm to mitigate the version number attack (VNA) demonstrates significant improvements in control overhead, energy consumption, and packet delivery ratio, optimizing node resources. Hybrid deep learning-based IDS systems have been proposed for classifying known and unknown abnormal behaviors in IoT traffic, achieving high accuracy and f1-scores, indicating the effectiveness of combining supervised and semi-supervised learning approaches. Counter-based detection algorithms for Flooding attacks in RPL protocol have shown high accuracy and improvements in throughput, delay time, and packet delivery ratio, highlighting the importance of monitoring network traffic. The chained secure mode (CSM) for RPL enhances resiliency against replay attacks and integrates with external security measures, offering better performance and security than traditional secure modes. Lastly, the energy-efficient multi-mobile agent-based trust framework (MMTM-RPL) mitigates internal attacks while minimizing energy and message overheads, enhancing the security and network lifetime. These theoretical solutions collectively contribute to the robust mitigation of risks in RPL for real-world IoT networks.What is the the updated CFIR framework?

The updated CFIR framework, known as CFIR 2.0, addresses important critiques and feedback from users to enhance its usability and applicability. The revisions include changes to existing domains and constructs, as well as additions, removals, or relocations of constructs to better center innovation recipients and incorporate determinants of equity in implementation. The CFIR 2.0 aims to facilitate the use of the framework, address thematic gaps, and improve the focus on recipients of innovation. These updates reflect the input from a growing community of CFIR users, ensuring that the framework evolves in line with advancements in implementation science. Users are encouraged to continue providing feedback to further refine and advance the CFIR framework.What is organizational theory?

Organizational theory encompasses a range of explanations regarding the interactions between organizations and their environments. It has evolved from various origins, including Max Weber's work on bureaucracies, business school theories focusing on management control, and industrial organization literature in economics. By applying organizational theories to governance processes, researchers can identify how organizational factors influence governance outcomes and potentially manipulate these factors to achieve desired goals. However, organizational theories are not immune to criticism, as they are often constructed through the re-signification of knowledge from other disciplines, leading to potential ideological biases and epistemological fragility. Overall, organizational theory is crucial in understanding how organizations function, adapt, and interact with their external environments, shaping both theoretical research and practical applications.What is the future of cellular and genetic therapy?

The future of cellular and genetic therapy is promising, with advancements aimed at overcoming current challenges and enhancing treatment efficacy. Innovations in manufacturing processes, such as the development of new techniques for nucleic acid manipulation and cell modification, are set to revolutionize therapy production, leading to more precise medicines with reduced costs and improved clinical outcomes. Additionally, genome engineering approaches, including CRISPR-Cas and synthetic biology, are enhancing the potency and control of cell therapies, paving the way for allogeneic therapy development and improved long-term persistence. Despite existing hurdles, cutting-edge research in genome editing, synthetic biology, and biomaterial utilization is addressing key challenges like identifying suitable cell sources and developing scalable manufacturing processes, driving the translation and commercialization of cell-based therapies.How technologies are affecting family relationships?

Technologies have a multifaceted impact on family relationships. Research indicates that ICT use can both strengthen and weaken family bonds. Personal ICT use and technoference often lead to negative outcomes, such as attention displacement and conflicts, particularly in romantic relationships. However, communication and co-use of technology within families generally have positive effects, promoting closeness and understanding. Moreover, the frequency of telephone and video calls mediates the relationship between family proximity and social isolation among older individuals, highlighting the role of technology in maintaining connections within families. Additionally, family technology use can create or amplify conflicts among parents, emphasizing the need to address this issue to maintain healthy family dynamics.What are the current trade-offs being made between security and energy efficiency in RPL networks?

In the realm of Internet of Things (IoT) networks, particularly those utilizing the Routing Protocol for Low-Power and Lossy Networks (RPL), there is a critical balance being struck between enhancing security measures and maintaining energy efficiency. The inherent design of RPL, while facilitating efficient routing in constrained environments, also exposes networks to various security vulnerabilities, including internal routing attacks that significantly degrade network performance and stability. These attacks not only compromise the quality of service (QoS) and topology stability but also lead to increased energy consumption and control traffic overhead, with some scenarios showing more than a 200% increase in energy consumption and network overhead. To counteract these vulnerabilities, several strategies have been proposed, each with its own trade-offs. For instance, the Rank Attack Detection (RAD) algorithm aims to preserve the integrity of control packets through a non-cryptographic hash algorithm and random sampling to reduce energy consumption. However, while it achieves better accuracy in certain topologies, it also necessitates a balance between detection efficiency and energy expenditure. Similarly, a modified version number attack demonstrates the severe impact of security breaches on network reliability, showing a drastic increase in overhead and energy consumption, which underscores the trade-off between securing the network and maintaining energy efficiency. Efforts to maximize energy efficiency in secure communication, such as optimizing beamforming vectors and direct current (DC) bias in visible light communication (VLC) networks, highlight the complex interplay between securing networks and optimizing energy use. These approaches show that while securing transmissions is crucial, it often comes at the cost of increased energy demands. The STACK project and other innovative solutions aim to mitigate attacks and improve transmission capabilities while closely monitoring performance and interference, yet they still face the challenge of integrating security without overly compromising energy efficiency. Moreover, the adoption of software-defined networking (SDN) approaches to reduce RPL control message overhead and energy consumption presents a promising avenue. By modifying control message formats and employing algorithms to determine the necessity of broadcasting messages, these methods can significantly reduce energy consumption by up to 60% compared to traditional approaches. However, the effectiveness of these security mechanisms against internal attacks remains limited, highlighting the ongoing challenge of enhancing security without exacerbating energy consumption. Innovative decentralized solutions for version number attacks offer a glimpse into the potential for reducing control overhead and energy usage by up to 58%, demonstrating a promising balance between security and energy efficiency. Furthermore, the exploration of physical-layer security (PLS) in RF energy harvesting networks introduces a nuanced understanding of the trade-offs between reliability and security, with dynamic power splitting relaying (DPSR) schemes showing potential for better balancing these aspects. In summary, the current landscape of RPL networks is characterized by a delicate balance between bolstering security to protect against various attacks and maintaining, or even enhancing, energy efficiency. While innovative solutions continue to emerge, the trade-offs between security and energy efficiency remain a central consideration in the design and optimization of IoT networks.