What is the role of ADP platelets in blood clotting?
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ADP plays a crucial role in blood clotting by amplifying platelet responses induced by other agonists, contributing to platelet aggregation and hemostasis. ADP activates platelets through purinergic receptors P2Y1 and P2Y12, essential for shape change, aggregation, and thrombus formation. Inhibition of ADP receptors prolongs clotting time in response to strong stimuli like collagen and thrombin, highlighting the significance of ADP in coagulation. Additionally, ADP is considered a co-factor in platelet activation, enhancing the effects of other agonists and aiding in the formation of pathological arterial thrombi. Understanding ADP's role in platelet function is crucial for developing effective anti-thrombotic drugs and managing thrombotic disorders.
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| Papers (4) | Insight |
|---|---|
| Platelet ADP plays a role in clotting by influencing clotting time when activated by strong stimuli like collagen or thrombin, but does not affect clot properties or fibrinolysis. | |
199 Citations | ADP activates platelets through P2Y1, P2Y12, and P2X1 receptors, crucial for shape change, aggregation, and thrombus formation, highlighting their significance in hemostasis and thrombosis. |
Open access•Journal Article 1 Citations | ADP platelets play a key role in platelet aggregation, aiding in the formation of coagulation clots and pathological arterial thrombi by interacting with ADP receptors on platelets. |
18 Citations | NAADP regulates human platelet function by releasing Ca2+ from stores, influencing platelet activation, secretion, aggregation, and clotting time, suggesting a potential target for anti-thrombotic therapy. |
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