S
Sridhar R. Vasudevan
Researcher at University of Oxford
Publications - 42
Citations - 1645
Sridhar R. Vasudevan is an academic researcher from University of Oxford. The author has contributed to research in topics: Circadian rhythm & Lithium (medication). The author has an hindex of 16, co-authored 39 publications receiving 1322 citations. Previous affiliations of Sridhar R. Vasudevan include University of Cambridge.
Papers
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Journal ArticleDOI
Identification of a chemical probe for NAADP by virtual screening
Edmund Naylor,Abdelilah Arredouani,Sridhar R. Vasudevan,Alexander M. Lewis,Raman Parkesh,Akiko Mizote,Daniel G. Rosen,Justyn M. Thomas,Minoru Izumi,Arasu Ganesan,Anthony Galione,Grant C. Churchill +11 more
TL;DR: The utility of Ned-19 as a chemical probe is shown by using it to demonstrate that NAADP is a key causal link between glucose sensing and Ca2+ increases in mouse pancreatic beta cells.
Journal ArticleDOI
A safe lithium mimetic for bipolar disorder
Nisha Singh,Amy C. Halliday,Justyn M. Thomas,Olga V. Kuznetsova,Rhiannon Baldwin,Esther C. Y. Woon,Esther C. Y. Woon,Parvinder K. Aley,Ivi Antoniadou,Trevor Sharp,Sridhar R. Vasudevan,Grant C. Churchill +11 more
TL;DR: Ebselen represents a lithium mimetic with the potential both to validate inositol monophosphatase inhibition as a treatment for bipolar disorder and to serve as a Treatment itself.
Journal ArticleDOI
The CRTC1-SIK1 pathway regulates entrainment of the circadian clock.
Aarti Jagannath,R Butler,R Butler,Godinho Sih.,Godinho Sih.,Yvonne Couch,Laurence A. Brown,Sridhar R. Vasudevan,Kevin C. Flanagan,Daniel C. Anthony,Grant C. Churchill,Wood Mja.,G Steiner,Martin Ebeling,M Hossbach,Joseph G. Wettstein,Giles E. Duffield,Silvia Gatti,Mark W. Hankins,Russell G. Foster,Stuart N. Peirson +20 more
TL;DR: Analysis of the light-regulated transcriptome of the SCN has identified a key role for salt inducible kinase 1 (SIK1) and CREB-regulated transcription coactivator 1 (CRTC1) in clock re-setting and provides a potential target for the regulation of circadian rhythms.
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The genetics of circadian rhythms, sleep and health
TL;DR: Treating clock disruption reverses and attenuates these adverse health states in animal models, thus establishing the circadian system as a novel therapeutic target, and focusing upon the genetics of circadian rhythms in sleep and health.
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Functionalized bis(thiosemicarbazonato) complexes of zinc and copper: synthetic platforms toward site-specific radiopharmaceuticals.
Jason P. Holland,Franklin I. Aigbirhio,Helen M. Betts,Paul D. Bonnitcha,Paul Burke,Martin Christlieb,Grant C. Churchill,Andrew R. Cowley,Jonathan R. Dilworth,Paul S. Donnelly,Jennifer C. Green,Josephine M. Peach,Sridhar R. Vasudevan,John E. Warren +13 more
TL;DR: Two new types of unsymmetrical bis(thiosemicarbazone) proligands and their neutral zinc( II) and copper(II) complexes have been synthesized and transmetalation is shown to be a viable method for radiolabeling compounds with copper radionuclides.