What is the role of brachyury in chordoma?
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Brachyury plays a crucial role in chordoma, a rare and aggressive bone cancer with notochordal differentiation. It is normally turned off in development and minimally expressed in healthy tissues, but remains highly expressed and required in chordoma . Brachyury acts as a transcription factor and promotes mesenchymal transition in a subset of common carcinomas, including chordoma . Efforts to target brachyury have been challenging due to the absence of ligand-accessible small-molecule binding pockets . However, recent studies have shown that direct and indirect targeting of brachyury can be effective in inhibiting chordoma growth. Direct targeting through brachyury degradation induces senescence, while indirect targeting through transcriptional inhibition causes apoptosis . These findings highlight brachyury as a promising therapeutic target in chordoma and provide insights into potential treatment strategies for this aggressive cancer .
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31 Mar 2023 | The paper states that brachyury (TBXT) acts as a putative oncogene in chordoma, a rare cancer showing notochordal differentiation. It promotes chordoma cell survival and is a potential therapeutic target. |
31 Mar 2023 | The paper states that brachyury (TBXT) acts as a putative oncogene in chordoma, a rare cancer showing notochordal differentiation. It promotes chordoma cell survival and is a potential therapeutic target. |
| Brachyury plays a critical role in chordoma by acting as a biomarker, regulating cell viability and tumor-initiating capacity, and mediating chordoma pathogenesis. | |
| The role of brachyury in chordoma is to act as an ultra-selective regulator and autoregulate through a transcriptional condensate. It is highly expressed and required in chordoma, despite being turned off in development and minimally expressed in healthy tissues. | |
| The paper states that the detection of brachyury is highly characteristic in chordomas, although not exclusive. However, it does not provide information on the specific role of brachyury in chordoma. |
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