What is the role of Cholesteryl esters on the skin surface lipids?
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Cholesteryl esters play a significant role in skin surface lipids by contributing to the protective barrier function of the skin. These esters are involved in maintaining the integrity of the stratum corneum structure, enhancing transdermal drug delivery, and acting as antioxidants against reactive oxygen species generated by environmental factors like solar radiation. Studies have shown that cholesteryl esters, particularly those derived from unsaturated fatty acids, can improve skin permeability without compromising the epidermal barrier. Additionally, cholesteryl esters have been identified as key components in the lipids coating the body cuticle of certain tick species, where they serve as sex pheromones, highlighting their diverse roles in skin biology and beyond.
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| Papers (5) | Insight |
|---|---|
| Cholesteryl esters on tick body surfaces, like in Hyalomma dromedarii and Rhipicephalus sanguineus, serve as mounting sex pheromones, influencing mating behavior and potentially minimizing heterospecific matings in nature. | |
9 Citations | Cholesteryl esters with alkyl branched fatty acids improve skin barrier function, water retention, and exhibit low skin irritation, making them beneficial for skin care products like cosmetics and bath additives. |
| Cholesteryl esters exhibit a distinct distribution in the stratum corneum, suggesting a unique role compared to other skin lipids, potentially influencing barrier function and penetration dynamics on the skin surface. | |
| Cholesteryl esters, specifically cholesterol, in skin surface lipids were not significantly affected by solar radiation, indicating a potential role in protecting against oxidative damage alongside squalene and vitamin E. | |
9 Citations | Cholesteryl esters, specifically unsaturated fatty acid esters of cholesterol, act as effective transdermal permeation enhancers, improving drug delivery through the skin barrier without compromising epidermal integrity. |
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