What is the role of genome instability in cancer?
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Genomic instability is a hallmark of cancer and plays a crucial role in its development and progression. It leads to the evolution of cancer cells with genomes different from normal cells, resulting in cell clones and heterogeneity within tumors and between tumors and metastatic sites . Replication stress, caused by obstacles in the DNA replication process, is a major driver of genome instability in cancer, particularly in triple-negative breast cancer (TNBC) . Whole-genome duplication (WGD) is another common genomic abnormality in cancer that contributes to genome instability, leading to an elevated risk of DNA damage and chromosomal instability . Chromosomal instability (CIN) is characterized by changes in chromosome structure or number and is regarded as a hallmark of cancer. CIN promotes tumor heterogeneity, therapy resistance, and metastasis, and is influenced by non-coding RNAs and other factors . Understanding the mechanisms and consequences of genome instability is crucial for developing effective therapeutic approaches for cancer treatment.
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| The paper discusses the role of chromosomal instability (CIN) in cancer, highlighting how it leads to genomic heterogeneity and contributes to tumor progression and resistance to therapy. | |
3 Citations | The paper discusses how chromosomal instability (CIN) plays a prevalent role in tumorigenesis and cancer progression by assisting cancer cells' phenotypic adaptation to stress, leading to therapy resistance and metastasis. |
| The role of genome instability in cancer is to promote deleterious cell division in most cells but enable cancer genome evolution to acquire growth advantages in a small subset of cells. | |
| Genomic instability drives the evolution of cancer cells, leading to differences in the genome compared to normal cells. It enables the development of cell clones and heterogeneity within and between tumors. (No answer found in the paper) | |
| Genome instability promotes the development of cancer by causing tumor heterogeneity and increasing the chances of adaptation to escape cancer therapeutic drugs. |
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