What is the role of MUC4 in the interaction with E-selectin during inflammation?
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MUC4 plays a role in the interaction with E-selectin during inflammation. It has been shown that MUC4β, a form of MUC4, forms a complex with the glucocorticoid receptor (GRα) in the nuclei of nasal polyp (NP) epithelial cells from corticosteroid-resistant patients . Additionally, MUC4 expression is increased in idiopathic pulmonary fibrosis (IPF) lungs and collaborates with TGFβ1 to induce epithelial to mesenchymal transition (EMT) and fibroblast to myofibroblast transition (FMT) cellular transformations . The structural and functional properties of the E-selectin ligands expressed by different monocyte and dendritic cell populations are key to understanding the biology of protective immunity and the pathobiology of several inflammatory diseases . Furthermore, Muc4 has been shown to drive intestinal inflammation and inflammation-associated tumorigenesis, as Muc4 knockout mice displayed increased resistance to colitis and reduced tumor burden in a colitis-induced tumor model .
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