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What is the role of sphingolipids in asthma and obesity associated asthma? 

Endoplasmic reticulum
Sphingosine-1-phosphate
Ceramide synthase
Allergic inflammation
Allergic sensitization
Best insight from top research papers

Sphingolipids play a multifaceted role in the pathogenesis of asthma and obesity-associated asthma, acting as critical signaling molecules that influence inflammation, immune cell activation, and airway hyperresponsiveness. In asthma, variations in sphingolipid concentrations, particularly ceramide and sphingosine-1-phosphate (S1P), have been strongly associated with the disease, influencing immune cell activation and allergic inflammation. Obesity further alters lipid metabolites, including sphingolipids, contributing to inflammation that may exacerbate asthma in obese individuals. Specifically, obese asthma patients exhibit higher levels of certain ceramides, indicating a metabolic shift favoring ceramide accumulation, which is linked to increased airway hyperresponsiveness and M1 macrophage polarization. Sphingomyelin (SM) levels, a type of sphingolipid, are significantly decreased in asthmatic patients compared to healthy controls, suggesting a protective role of SM against asthma. Environmental factors, such as exposure to pollutants, have been shown to affect sphingolipid levels, including S1P and ceramide-1-phosphate (C1P), potentially defining a novel asthma endotype influenced by environmental exposures. Genetic factors also play a role, with certain genetic loci associated with asthma influencing the expression of ORMDL3, a regulator of sphingolipid synthesis, thereby affecting sphingolipid levels and asthma susceptibility. In the context of obesity, elevated serum triglycerides, another lipid class, have been associated with asthma, suggesting a link between lipid metabolism and asthma in obese patients. Sphingolipid metabolism's disruption is strongly associated with diseases exhibiting metabolic consequences, including obesity. Furthermore, sphingolipid metabolites like S1P are involved in mast cell differentiation, proliferation, and inflammatory responses, highlighting their role in allergic diseases and asthma pathogenesis. In summary, sphingolipids contribute to asthma and obesity-associated asthma through their roles in inflammation, immune cell regulation, and response to environmental and genetic factors, offering potential targets for therapeutic intervention.

Answers from top 10 papers

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Papers (10)Insight
Open access•Journal Article•DOI
Role of Sphingosine-1-Phosphate in Mast Cell Functions and Asthma and Its Regulation by Non-Coding RNA.
Rohit Saluja, Ashok Kumar, Manju Jain, Sudhir K. Goel, Aklank Jain 
22 May 2017-Frontiers in Immunology
26 Citations
Sphingosine-1-phosphate (S1P) plays a crucial role in mast cell functions in asthma. However, the paper does not address the specific role of sphingolipids in obesity-associated asthma.
Open access•Journal Article•DOI
Sphingolipids in obesity and related complications.
Krishna M. Boini, Min Xia, Saisudha Koka, Todd W.B. Gehr, Pin-Lan Li 
01 Jan 2017-Frontiers in Bioscience
32 Citations
Not addressed in the paper.
Journal Article•DOI
Association between elevated serum triglycerides and asthma in patients with obesity: An explorative study
Cathelijne M van Zelst, Geertje M. de Boer, Yasemin Türk, Astrid van Huisstede, Johannes C C M In 't Veen, Erwin Birnie, Bianca M Boxma-de Klerk, Gerdien A. Tramper-Stranders, Gert-Jan Braunstahl 
01 May 2021-Allergy and Asthma Proceedings
4 Citations
Not addressed in the paper.
Open access•Journal Article•DOI
Sphingolipids and their enigmatic role in asthma
Jamie Sturgill
01 Dec 2018-Advances in biological regulation
21 Citations
Sphingolipids play a crucial role in asthma by influencing mast cell biology. The paper does not address the specific role of sphingolipids in obesity-associated asthma.
Open access•Journal Article•DOI
Solving the Riddle: Targeting the Imbalance of Sphingolipids in Asthma to Oppose Airway Hyperresponsiveness
Maggie Lam, Jane E. Bourke 
30 Oct 2020-American Journal of Respiratory Cell and Molecular Biology
4 Citations
Sphingolipids play a dual role in asthma, influencing airway hyperresponsiveness. While altered levels contribute to asthma pathophysiology, their manipulation shows promise in opposing airway hyperresponsiveness.
Open access•Journal Article•DOI
The Role of Sphingolipids in Allergic Disorders
Araceli Díaz-Perales, María M. Escribese, María Garrido-Arandia, David Obeso, Elena Izquierdo-Alvarez, Jaime Tome-Amat, Domingo Barber 
14 Jun 2021
8 Citations
Sphingolipids play a crucial role in asthma by regulating inflammation and barrier integrity. While not directly addressed in the paper, their involvement in obesity-associated asthma warrants further investigation.
Book Chapter•DOI
Sphingolipids and Asthma.
Tilla S. Worgall
01 Jan 2022-Advances in Experimental Medicine and Biology
1 Citations
Sphingolipids play a crucial role in asthma by influencing airway features. The paper does not address the specific link between sphingolipids and obesity-associated asthma.
Journal Article•DOI
Environmental exposures: another effect on sphingolipids in asthma?
Stefan Worgall
11 Nov 2022-Thorax
Sphingolipids, particularly S1P and C1P, are elevated in asthma, potentially influenced by environmental pollutants. Their role in obesity-associated asthma is not addressed in the paper.
Journal Article•DOI
Serum sphingolipid profile in asthma.
Chenglin Guo, Lina Sun, Linlin Zhang, Fawu Dong, Xu Zhang, Liu Yao, Chun Chang 
18 Feb 2021-Journal of Leukocyte Biology
7 Citations
Sphingolipids, particularly sphingomyelin (SM), are decreased in asthma patients. SM levels are lower in noneosinophilic asthma and may serve as a biomarker and therapeutic target in asthma.
Journal Article•DOI
Metabolic shift favoring C18:0 ceramide accumulation in obese asthma.
Youngwoo Choi, Min-Ji Kim, Su Jung Kim, Hyun-Ju Yoo, Seung-Hyun Kim, Hae-Sim Park 
01 Nov 2020-Allergy
14 Citations
Sphingolipids, particularly C18:0 ceramide, accumulate in obese asthma, potentially contributing to its development by favoring ceramide accumulation and metabolic shifts, leading to inflammation and airway hyperresponsiveness.

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