What is the role of the CHEK2 gene in the development of medullary thyroid cancer?
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The CHEK2 gene has been found to play a role in the development of various cancers, including breast, ovarian, prostate, and thyroid cancer. Several studies have investigated the association between CHEK2 germline mutations and thyroid cancer, particularly papillary thyroid carcinoma (PTC). In a study by Gąsior-Perczak et al., CHEK2 mutations were detected in 15.5% of PTC patients, with truncating mutations being more common in women and associated with vascular invasion and intermediate/high initial risk. Another study by Carolina Pires et al. identified a germline pathogenic frameshift variant in the CHEK2 gene in a Portuguese family with familial non-medullary thyroid carcinoma (FNMTC). However, there is no mention of the role of CHEK2 in medullary thyroid cancer specifically in the provided abstracts. Therefore, the role of the CHEK2 gene in the development of medullary thyroid cancer is not addressed in the available literature.
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4 Citations | The provided paper does not mention the role of the CHEK2 gene in the development of medullary thyroid cancer. |
3 Citations | The provided paper does not mention the role of the CHEK2 gene in the development of medullary thyroid cancer. |
01 Jan 2022 | The paper does not mention the role of the CHEK2 gene in the development of medullary thyroid cancer. The paper discusses the significance of germline mutations in the CHEK2 gene and their association with various cancers, but does not specifically mention medullary thyroid cancer. |
2 Citations | The provided paper does not mention the role of the CHEK2 gene in the development of medullary thyroid cancer. The paper focuses on the identification of a pathogenic variant in the CHEK2 gene in Portuguese Roma patients with papillary thyroid carcinoma and multinodular goiter. |
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