What is the role of the secretory aspartyl protease in Candida albicans?
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Secretory aspartyl proteases in Candida albicans play a crucial role in the pathogenesis of candidiasis. These proteases contribute to fungal virulence by promoting host tissue and cell damage, hijacking immune responses, and facilitating invasion and survival of the pathogen . They are involved in the degradation of host proteins, including major proteolytic cascades such as the blood coagulation, kallikrein-kinin system, and complement system . Additionally, they impair the activity of host proteases by degrading specific endogenous inhibitors and inactivate antimicrobial peptides and proteins produced by host cells . The degradation of important host proteins facilitates fungal adhesion to host cell surfaces, promotes tissue damage, and enables the dissemination of the pathogen . The multiple roles of secretory aspartyl proteases in host-pathogen interactions during candidiasis make them potential targets for novel antifungal therapies .
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| Papers (5) | Insight |
|---|---|
01 Jan 2017 2 Citations | The secreted aspartic proteases in Candida albicans play a critical role in the destruction of host proteins and tissues, leading to the development and propagation of fungal infections. |
| The provided paper is about the secretome characterization of Candida glabrata, not Candida albicans. Therefore, the paper does not provide information about the role of secretory aspartyl protease in Candida albicans. | |
3 Citations | The provided paper is about the secreted aspartyl peptidases in the Candida haemulonii complex, not Candida albicans. Therefore, the paper does not provide information about the role of secretory aspartyl protease in Candida albicans. |
| The secretory aspartyl protease in Candida albicans, specifically Sap6, contributes to fungal virulence in oral candidiasis by activating immune cells and inducing proinflammatory cytokines. | |
21 Aug 2019 | The provided paper is about the role of secreted aspartyl proteases (Sap) in Candida parapsilosis, not Candida albicans. The paper does not provide information about the role of secretory aspartyl proteases in Candida albicans. |
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