What is type two diabetes?
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Type 2 diabetes, a chronic metabolic disease, is characterized by insulin resistance, β-cell production decline, and oxidative stress markers like malondialdehyde and hydroxynonenal . Its global incidence is rising, with no cure available. Diagnosis involves elevated plasma glucose levels and hyperglycemic symptoms . Management includes lifestyle changes, medication like metformin, and herbal remedies. New treatments like GLP-1 analogues and SGLT2 inhibitors are emerging . Exercise plays a crucial role in managing type 2 diabetes by improving insulin resistance and cardiovascular risk factors . Chronic hyperglycemia in diabetes can lead to severe complications affecting various organ systems, including microvascular and macrovascular issues, significantly increasing the risk of cardiovascular diseases .
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| Papers (5) | Insight |
|---|---|
| Diabetes Mellitus Type 2 is a chronic metabolic disorder characterized by persistent hyperglycemia due to impaired insulin secretion, resistance to insulin, or both, leading to severe health complications. | |
4 Citations | Type 2 diabetes mellitus is a chronic metabolic condition characterized by insulin resistance and high blood sugar levels, with treatment options including lifestyle changes, medications, and herbal remedies. |
| Type 2 diabetes, also known as diabetes mellitus type 2 (DM2), is characterized by insulin resistance due to excess energy in visceral fat, liver, and muscle, leading to high blood glucose levels. | |
| Type 2 diabetes is a complex disease affecting 90% of individuals with diabetes, impacting insulin action in muscle cells and requiring management of glucose, blood pressure, and lipids for cardiovascular health. | |
| Type 2 diabetes is a chronic metabolic disease characterized by insulin resistance, β-cell decline, and oxidative stress. It is influenced by various risk factors and associated with multiple complications. |
Related Questions
What is Diabetes?5 answersDiabetes is a chronic metabolic disease characterized by high levels of glucose in the blood. It can occur due to the pancreas not producing enough insulin (type 1 diabetes) or the body's reduced ability to produce or respond to insulin (type 2 diabetes). People with diabetes are at a greater risk of developing cardiovascular diseases, vision loss, foot and leg amputation, and renal failure. Currently available pharmacotherapy for diabetes includes insulin and oral hypoglycemic agents, but they have limitations and side effects. Herbal drugs have also shown effectiveness in treating diabetes. Diabetes and its complications are a significant public health problem worldwide, with the prevalence expected to continue rising. Obesity is a major contributing factor to the increase in type 2 diabetes cases.
What is diabetes type 2?4 answersType 2 diabetes is a chronic metabolic disease characterized by insulin resistance and a decline in β-cell production. It is associated with various risk factors, including non-modifiable ones such as age, family history, and ethnicity, as well as modifiable ones like obesity and hypertension. Insulin resistance, often caused by an excess of energy in visceral fat, liver, and muscle tissue, leads to elevated blood glucose levels. Skeletal muscle is the primary site of insulin action, responsible for the majority of glucose uptake in the body. Carbohydrate-restricted diets have been effective in managing type 2 diabetes by reducing glucose and insulin levels. If left untreated, type 2 diabetes can lead to various complications. Awareness campaigns and lifestyle modifications can help reduce the risk of developing type 2 diabetes.
What is Diabetes?4 answersDiabetes is a group of metabolic diseases characterized by high blood sugar levels. It can be caused by the body's inability to produce enough insulin or by cells not responding properly to the insulin that is produced. There are three main types of diabetes: Type 1 diabetes, which is insulin-dependent and usually develops in childhood; Type 2 diabetes, which is non-insulin dependent and often associated with lifestyle factors such as obesity; and gestational diabetes, which occurs during pregnancy. Diabetes can lead to complications such as damage to organs, reduced energy levels, and other health problems. The prevalence of diabetes is increasing globally, with significant economic and health impacts. Current treatments for diabetes include insulin and oral hypoglycemic agents, but they may have side effects and do not restore normal glucose homeostasis. Herbal drugs have also shown promise in diabetes treatment. It is important to take steps to screen, prevent, and manage diabetes in order to control this growing epidemic.
What is the definition of diabetes?4 answersDiabetes is a chronic metabolic disease characterized by high levels of glucose in the blood. It can occur due to the pancreas not producing enough insulin (type 1 diabetes) or the body's reduced ability to produce or respond to insulin (type 2 diabetes). People with diabetes are at a greater risk of developing cardiovascular diseases, vision loss, foot and leg amputation, and renal failure. Various pharmacotherapy options are available, including insulin and oral hypoglycemic agents, but they may have side effects and do not restore normal glucose homeostasis. Herbal drugs have also shown effectiveness in treating diabetes. The prevalence of diabetes is increasing globally, and it is a significant health problem causing morbidity and mortality.
What is type 2 diabetes?4 answersType 2 diabetes mellitus (T2DM) is a common metabolic disorder characterized by chronic hyperglycemia. It is associated with reduced life expectancy due to a greater risk of heart disease, stroke, peripheral neuropathy, renal disease, blindness, and amputation. T2DM is the most common clinical form of diabetes, accounting for about 90% of all cases. It typically affects adults over the age of 40 years and is strongly associated with obesity, inactivity, family history of diabetes, and ethnic background. The disease is heterogeneous and encompasses a group of hyperglycemic disorders with multiple different mechanisms. The best-known predictors of increased diabetes risk are elevated fasting plasma glucose, abnormal glucose tolerance test, obesity, and evidence of impaired insulin action. T2DM is a major cause of disability and suffering, and it incurs significant healthcare costs. The pathophysiology of T2DM involves defects in insulin secretion, insulin action, or both.
What causes diabetes type 2?2 answersType 2 diabetes is caused by a combination of genetic and non-genetic factors. Genetic factors play a role in predisposing individuals to the disease, with around 250 genomic regions implicated in its development. These genetic factors interact with non-genetic factors such as obesity, physical inactivity, poor diet, age, gender, education, lifestyle, food, stress, socio-economic status, and physical activity. The disease is also influenced by the interplay between β-cell failure, insulin sensitivity, appetite regulation, and adipose storage. Additionally, recent data suggest that beta-cell dedifferentiation may contribute to reduced insulin secretion in type 2 diabetes. Prevention and early intervention are crucial in managing type 2 diabetes, with lifestyle changes and pharmacological treatments aimed at reducing cardiovascular risk and controlling weight. There is a need for effective public health strategies to reduce the incidence of type 2 diabetes and for further research to develop superior treatments or a cure.