What is warburg effect in cancer?
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The Warburg effect in cancer refers to the phenomenon where cancer cells preferentially use glycolysis for energy production, even in the presence of sufficient oxygen. This metabolic reprogramming allows cancer cells to rapidly generate ATP and provide intermediates for anabolic reactions, supporting their proliferation and growth . The Warburg effect is characterized by increased glucose uptake and glycolysis, leading to the production of lactate as a byproduct . Initially, lactate was thought to be a waste product, but it has been found to serve as an important oxidative fuel and signaling molecule in cancer cells . The Warburg effect also contributes to immune evasion by creating an acidic tumor microenvironment that inhibits macrophage-mediated phagocytosis . Understanding the mechanisms underlying the Warburg effect is crucial for developing targeted therapies against cancer metabolism .
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| The Warburg effect in cancer refers to the increased glucose uptake and glycolysis in cancer cells, which provides energy and intermediates for cell proliferation. The accompanying increased lactate production is explained by the need to regenerate NAD+ for glycolysis and as an oxidative fuel. | |
10 Citations | The Warburg effect in cancer refers to the preference of cancer cells for glycolysis, even in the presence of sufficient oxygen, leading to increased lactate production. |
6 Citations | The paper discusses the Warburg effect, which is the observation that cancer cells rely more on glycolysis for ATP generation rather than oxidative phosphorylation. |
| The Warburg effect in cancer refers to the phenomenon where cancer cells obtain energy through glycolysis, producing lactate and pyruvate, regardless of the presence of oxygen. This metabolic abnormality is a hallmark of many human cancers. |
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