Where do long range vip projection neurons come from?
Long-range VIP projection neurons originate from the auditory and motor cortices in mice, as demonstrated by anatomical anterograde and retrograde viral tracing . These VIP-expressing neurons send GABAergic projections to various cortical and subcortical regions, including the contralateral auditory cortex, ipsilateral striatum, amygdala, medial geniculate body, superior and inferior colliculus, dorsal striatum, and contralateral cortex . VIP-expressing inhibitory interneurons in the primary motor cortex (MOp) receive inputs from the orbital frontal cortex (ORB), associated with reinforcement learning and value predictions, indicating their role in integrating reward-related information for local circuit plasticity during motor learning . Additionally, in the hippocampus, VIP+ interneurons known as VIP-LRPs innervate CA1 and project to the subiculum, showing molecular diversity and functional specialization in controlling cell ensembles along the hippocampo-subicular axis .
Answers from top 5 papers
Papers (5) | Insight |
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Long-range VIP projection neurons in the hippocampus originate from a novel type of VIP+ neuron, VIP-LRPs, which target interneurons in CA1 and both interneurons and pyramidal cells in the subiculum. | |
54 Citations | Long-range VIP projection neurons in the hippocampus originate from a distinct population of VIP-expressing GABAergic neurons with specific molecular properties and region-specific connectivity patterns. |
95 Citations | Long-range VIP projection neurons originate from the ventral tegmental area (VTA) in the mouse brain, with distinct subtypes targeting forebrain structures and exhibiting diverse axonal wiring architectures. |
Long-range VIP projection neurons to the primary motor cortex originate mainly from the orbital frontal cortex (ORB), associated with reinforcement learning and value predictions, as per the study. | |
5 Citations | Long-range VIP GABAergic projection neurons originate from the auditory and motor cortices in mice, extending to various cortical and subcortical regions, as demonstrated in the study. |