Which are the clinical trial phase III of HER2 positive breast cancer ?
Phase III clinical trials for HER2-positive breast cancer mentioned in the abstracts include: 1. Yang et al. conducted a phase III trial to evaluate the efficacy of non-cross-resistant adjuvant chemotherapy in patients with HR+/HER2-/LN+ breast cancer who were non-responsive to primary chemotherapy . 2. Patel et al. described a phase III trial (NCT05232916) investigating the addition of GP2 therapy to trastuzumab-based therapy as maintenance treatment for HER2-positive breast cancer . 3. Hamilton et al. presented the HER2CLIMB-05 trial, a phase III study evaluating the addition of tucatinib to standard of care (SOC) as maintenance therapy for HER2-positive metastatic breast cancer . 4. Another phase III study, PHEDRA, assessed the addition of pyrotinib to trastuzumab and docetaxel in the neoadjuvant setting for HER2-positive early or locally advanced breast cancer . Please note that these are the clinical trials mentioned in the abstracts provided, and there may be other ongoing or completed phase III trials for HER2-positive breast cancer not mentioned here.
Answers from top 4 papers
Papers (4) | Insight |
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The clinical trial phase III mentioned in the paper is the PHEDRA trial, which evaluated neoadjuvant pyrotinib, trastuzumab, and docetaxel for HER2-positive breast cancer. | |
The clinical trial phase III for HER2 positive breast cancer mentioned in the paper is HER2CLIMB-05, which is evaluating tucatinib plus trastuzumab and pertuzumab as maintenance therapy. | |
The provided paper is about the phase 3 study of tucatinib or placebo in combination with trastuzumab and pertuzumab as maintenance therapy for HER2+ metastatic breast cancer (HER2CLIMB-05, trial in progress). However, it does not provide information about other phase III clinical trials for HER2 positive breast cancer. | |
The clinical trial phase III for HER2 positive breast cancer mentioned in the paper is the ###122TiP Phase III study to evaluate the efficacy and safety of GLSI-100 (GP2 + GM-CSF) in breast cancer patients with residual disease or high-risk PCR after both neo-adjuvant and postoperative adjuvant anti-HER2 therapy, Flamingo-01###. |