Which compound undergoes hydrolysis faster, a ketone or a lactone ?
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Lactones undergo hydrolysis faster compared to ketones . The hydrolysis of lactones is a significant process, especially in the context of pharmaceuticals, where lactone hydrolysis affects both bioavailability and efficacy of drugs containing lactones. Studies have shown that the hydrolysis of lactones can be influenced by various factors such as the structure of the lactone ring and the pH of the medium. In contrast, ketones can also undergo hydrolysis to form lactones, but the rate of hydrolysis for lactones is generally faster than that of ketones. This difference in hydrolysis rates between lactones and ketones underscores the importance of understanding the reactivity of these compounds in various chemical and biological processes.
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13 Citations | Lactones undergo hydrolysis faster than ketones due to both enzymatic and nonenzymatic processes, impacting bioavailability and efficacy of pharmaceuticals containing lactones. |
| Ketones undergo hydrolysis faster than lactones in the reaction of iminium ethers derived from ketones with hydroxy azides, yielding lactams and lactones depending on reactant structures and pH. | |
| Lactones undergo hydrolysis faster than ketones, as shown in the study where β-aryl-γ-ethylidene-γ-lactones were hydrolyzed by Aspergillus ochraceus AM370 to form γ-ethylidene-γ-lactones and ketoacids. | |
| Lactones undergo hydrolysis faster based on the study's multiple linear regression models predicting base-catalyzed rate constants, showing higher accuracy for lactones compared to carboxylic acid esters. |
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