Which part of anterior insular cortex is related to pain, dorsal or ventral?
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The dorsal anterior insula is related to pain intensity and represents signed prediction errors specific to pain, while the ventral anterior insula represents pain intensity, expectations, and their absolute difference (i.e., the prediction error) . The left anterior insula cortex is dysregulated in chronic pain patients and represents a robust neurofunctional maladaptation . The anterior insula, particularly the anterior insular region, is a key node in an extended bilateral insula-fronto-cingular network involved in pain-related processes . The anterior insula, specifically the anterior insular and opercular cortices contralateral to painful stimulation, shows activation correlated with unsigned intensity prediction errors, which are similar for pain and aversive sounds . The rostral agranular insular cortex (RAIC) is associated with pain modulation, and the activation of cannabinoid receptor 1 (CB1R) in GABAergic neurons in the RAIC induces an analgesic effect in neuropathic pain .
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| The paper does not specifically mention whether the dorsal or ventral part of the anterior insular cortex is related to pain. | |
| The paper does not explicitly mention whether the dorsal or ventral part of the anterior insular cortex is related to pain. | |
| The ventral anterior insula is related to pain, as it represents pain intensity, expectation, and the prediction error, while the dorsal anterior insula only represents pain intensity. | |
7 Citations | The paper does not specify whether the dorsal or ventral part of the anterior insular cortex is related to pain. |
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