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Why sometimes the crispr sistem reconginez trasposases and resolvas and not virus?

Mobile genetic elements

DNA Integration

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The CRISPR-Cas system can sometimes recognize and interact with transposons rather than viruses. This unique phenomenon involves the co-option of nuclease-deficient CRISPR-Cas systems by bacterial Tn7-like transposons to catalyze RNA-guided integration of mobile genetic elements into the genome . This process requires a complex interplay between CRISPR- and transposon-associated molecular machineries, showcasing a notable inversion of the system's conventional role in combating viruses and plasmids. The programmable transposition of transposons like Vibrio cholerae Tn6677 in Escherichia coli demonstrates how CRISPR-Cas systems can be repurposed for genomic manipulations beyond viral defense, enabling precise integration of genetic payloads without the need for double-strand breaks or homology-directed repair. This discovery highlights the versatility and adaptability of CRISPR-Cas systems in mediating interactions with diverse genetic elements .

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Book Chapter•DOI CRISPR-Cas Systems to Probe Ecological Diversity and Host–Viral Interactions Nicole L. Held, Lauren M. Childs, Michelle Davison, Michelle Davison, Joshua S. Weitz, Rachel J. Whitaker, Devaki Bhaya - Show less +6 more 01 Jan 2013 11 Citations	CRISPR-Cas systems recognize and resolve transposases because they can acquire novel spacers rapidly, while viruses mutate quickly, evading the system's immunity based on spacer matching.
Journal Article•DOI Non-viral and viral delivery systems for CRISPR-Cas9 technology in the biomedical field Zhiyao He, Ke Men, Zhou Qin, Yang Yang, Ting Xu, Yuquan Wei - Show less +5 more 02 May 2017-Science China-life Sciences 42 Citations	Not addressed in the paper.
Journal Article•DOI Transposon-encoded CRISPR–Cas systems direct RNA-guided DNA integration Sanne E. Klompe, Phuc Leo H. Vo, Tyler S. Halpin-Healy, Samuel H. Sternberg - Show less +3 more 12 Jun 2019-Nature 359 Citations	Transposon-encoded CRISPR-Cas systems integrate genetic elements into the genome, unlike conventional systems that target viruses. This unique mechanism involves RNA-guided DNA integration by Tn7-like transposons.
Open access CRISPR systems in microbiomes Anna Gogleva, Irena I. Artamonova - Show less +1 more 01 Jan 2013	CRISPR systems recognize and resolve transposases because they provide resistance against alien replicons like viruses and plasmids, retaining a footprint of prokaryote-virus interactions in microbiomes.

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